T9514
Tetrahydropapaverine hydrochloride
≥90%, powder
Synonym(s):
6,7-Dimethoxy-1-(3,4-dimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline
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About This Item
Empirical Formula (Hill Notation):
C20H25NO4 · HCl
CAS Number:
Molecular Weight:
379.88
EC Number:
MDL number:
UNSPSC Code:
12352200
Recommended Products
Assay
≥90%
form
powder
color
white
solubility
H2O: soluble
storage temp.
2-8°C
SMILES string
Cl.COc1ccc(CC2NCCc3cc(OC)c(OC)cc23)cc1OC
Biochem/physiol Actions
Phosphodiesterase inhibitor.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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I Koshimura et al.
Brain research, 773(1-2), 108-116 (1997-12-31)
We report the toxic effects of 3,4-dimethoxyphenylethylamine (DMPEA), and tetrahydropapaverine (THP) on the rat nigrostriatal system; THP is a tetrahydroisoquinoline compound which may be derived from DMPEA by conjugation of DMPEA and its oxidative metabolite, dimethoxyphenylacetaldehyde; both are potent inhibitors
S Hosztafi et al.
Pharmacological research, 32(1-2), 15-20 (1995-07-01)
This review surveys the discovery of endogenous alkaloids in mammals. The formation of morphine in mammalian brain was assumed in 1970. The existence of morphine was demonstrated by radioimmunoassay. Identification of morphine was performed by spectroscopic methods. The isolation of
Eung Il Kim et al.
Life sciences, 75(16), 1949-1957 (2004-08-13)
The inhibitory effects of tetrahydropapaverine on serotonin biosynthesis in serotonin-producing murine mastocytoma P815 cells were investigated. Tetrahydropapaverine at concentration ranges of 5-20 microM decreased serotonin content in a concentration-dependent manner in P815 cells and showed 42.1% inhibition of serotonin content
F S Messiha
Veterinary and human toxicology, 32(2), 126-130 (1990-04-01)
The effects of tetrahydropapaverine (THP) and papaverine (PAP), an O-methylated analogue, on rat liver alcohol dehydrogenase (L-ADH) and aldehyde-dehydrogenase (L-ALDH) were studied in vitro. The action of THP on these enzymes was also evaluated in vivo in conjunction with its
K Suzuki et al.
Neurochemical research, 15(7), 705-710 (1990-07-01)
Since the discovery of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism, it has been postulated that (a) MPTP-like toxin(s) such as 1,2,3,4-tetrahydroisoquinoline (TIQ) may induce Parkinson's disease. As the neuronal degeneration in MPTP-induced parkinsonism is thought to be caused by the inhibition of the
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