SML0487
CID 2818500
≥98% (HPLC)
Synonym(s):
(Z)-α-Nitrostilbene, 1,1′-[(1Z)-1-Nitro-1,2-ethenediyl]bis-benzene, trans-α-Nitrostilbene
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About This Item
Empirical Formula (Hill Notation):
C14H11NO2
CAS Number:
Molecular Weight:
225.24
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
room temp
Biochem/physiol Actions
CID 2818500 (trans-α-Nitrostilbene; 1,1′-[(1Z)-1-Nitro-1,2-ethenediyl]bis-benzene) is a selective inhibitor of Protein Arginine Methyltransferases PRMT1 and PRMT8.
CID 2818500 (trans-α-Nitrostilbene; 1,1′-[(1Z)-1-Nitro-1,2-ethenediyl]bis-benzene) is a selective inhibitor of Protein Arginine Methyltransferases PRMT1 and PRMT8. PRMT1 is responsible for the majority of arginine methylation in the cell involved in transcription, chromatin modification, and signal transduction. CID 2818500 has an IC50 values of 11 μM for PRMT1, and does not inhibit PRMTs 3, 4, and 6, although it does inhibit PRMT8. The mechanism is believed to involve a specific S-adenosylmethionine (SAM)-binding cysteine present only in the Type I PRMTs PRMT1 and PRMT8 and absent in other SAM-dependent methyltransferases.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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