SCP0008
[DArg0,Hyp3,Thi5,8,DPhe7]-Adamantaneacetyl Bradykinin
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About This Item
Empirical Formula (Hill Notation):
C68H99N19O14S2
Molecular Weight:
1470.76
UNSPSC Code:
12352209
NACRES:
NA.32
Pricing and availability is not currently available.
Assay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥70%
storage condition
protect from light
storage temp.
−20°C
Amino Acid Sequence
Ada-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-Phe-Thi-Arg
Application
Bradykinin, a nonapeptide, is a potent endothelium-dependent vasodilator that operates via bradykinin receptors B1 and B2. Adamantaneacetyl Bradykinin (NA-BK) and [DArg0,Hyp3,Thi5,8,DPhe7]-Adamantaneacetyl Bradykinin are used as a B2 bradykinin receptor antagonists.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Galia K Soukhova-O'Hare et al.
Life sciences, 78(17), 1990-1997 (2005-11-18)
Endogenous bradykinin (BK) is an established mediator of pulmonary inflammation, yet its role in lung disease is unclear. In the rabbit, injecting BK into the lung parenchyma elicits reflex hyperpnea, tachypnea, hypotension, and bradycardia by stimulating pulmonary sympathetic afferents. To
W D Ehringer et al.
Inflammation, 21(3), 279-298 (1997-06-01)
alpha-Thrombin (AT) and bradykinin (BK) are endogenous mediators that are released during an inflammatory response, and could have a synergistic effect on endothelial permeability. Human umbilical vein endothelial cells (HUVEC) were grown on Transwell membranes and then tested for alterations
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