Solutions prepared at 1 mg/ml may be stored up to 8 weeks at 2 - 8°C or 20°C. This material decomposes rapidly in acidic or alkaline conditions. Solutions are most stable when prepared in degassed water and at neutral pH. Avoid repeated freeze/thaw cycles.
SBR00067
Rifampicin Water Soluble
solubility: 50 mg/mL in water, freely soluble
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About This Item
UNSPSC Code:
51283601
NACRES:
NA.76
Pricing and availability is not currently available.
Recommended Products
form
solid
Quality Level
specific activity
(Antibacterial)
solubility
water: freely soluble 50 mg/mL
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
mycobacteria
viruses
Mode of action
protein synthesis | interferes
storage temp.
−20°C
General description
Rifampicin is used to treat Tuberculosis and Tuberculosis-related mycobacterial infections.[1] Rifampicin is widely used as an antipruritic agent in the autoimmune cholestatic liver disease, and primary biliary cirrhosis (PBC).[2] Rifampicin was also found active by inhibiting Tau Oligomer Propagation in Alzheimer’s disease.[3] In addition, Rifampicin is used as a selection agent for agrobacterium mediated plant transformation.[4]
Application
Rifampicin is used to treat Tuberculosis and Tuberculosis-related mycobacterial infections. It is widely used as an antipruritic agent in the autoimmune cholestatic liver disease, primary biliary cirrhosis (PBC). It has been shown to cause hepatitis.
Biochem/physiol Actions
Rifampicin inhibits the assembly of DNA and protein into mature virus particles. It inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase, which results in cell death.
Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase. Inhibits the assembly of DNA and protein into mature virus particles.
Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase. Inhibits the assembly of DNA and protein into mature virus particles.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Specific packaging of custom RNA molecules into cowpea mosaic virus-like particles.
Peyret, Hadrien, et al
Recombinant proteins from plants: production and isolation of clinically useful compounds, 103-111 (2022)
Guidelines for the Management of Cholestatic Liver Diseases (2021)
Lu, Lungen
Journal of clinical and translational hepatology (2022)
Treatment of rifampicin-resistant tuberculosis disease and infection in children: key updates, challenges and opportunities
Howell, Pauline, et al.
Pathogens (Basel, Switzerland), 11.4, 381-381 (2022)
Tomohiro Umeda et al.
Biomedicines, 10(2), 297-297 (2022-02-26)
The cell-to-cell transmission of tau aggregates is considered a mechanism underlying the intracerebral spreading of tau pathology in Alzheimer's disease (AD) and other tauopathies. Recent studies suggest that tau oligomers, rather than fibrils, participate in this process. We previously showed
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SBR00067-- I plan to dissolve in water and aliquot in 1 ml amounts. At what temperature should the aliquotes be stored and upto how long it can be stored ( e- -20 C/-70C) After dissolving in water, how long the solution can be stored at -20 C
1 answer-
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