Anti-Synuclein β antibody detects endogenous levels of total Synuclein β protein.
The SNCB (synuclein β) gene is mapped to the chromosome 5q35.2. Synuclein β is known to localize along with synuclein α in the presynaptic region of the brain. It contains KTKXGV repeats at its N-terminal, highly acidic and solubilizing region at its C-terminal and a non-amyloid-β component.
Immunogen
The antiserum was produced against synthesized peptide derived from human Synuclein beta.
Immunogen Range: 85-134
Biochem/physiol Actions
Synuclein β reduces the effects of synuclein α toxicity in a dose dependent manner by preventing its accumulation. Synuclein β normally, does not form fibrils.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
The loss of inhibitory C-terminal conformations in disease associated P123H ?-synuclein.
Janowska MK and Baum J
Protein Science, 25(1), 286-294 (2016)
Prenatal diagnosis and molecular cytogenetic characterization of a 1.07-Mb microdeletion at 5q35.2-q35.3 associated with NSD1 haploinsufficiency and Sotos syndrome.
Chen CP
Taiwanese Journal of Obstetrics & Gynecology, 53(4), 583-587 (2014)
Intercellular transfer of toxic proteins between neurons is thought to contribute to neurodegenerative disease, but whether direct interneuronal protein transfer occurs in the healthy brain is not clear. To assess the prevalence and identity of transferred proteins and the cellular
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