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SAB4500429

Sigma-Aldrich

Anti-ADORA2B antibody produced in rabbit

affinity isolated antibody

Synonym(s):

ADORA2B, Adenosine receptor A2b

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 36 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBI accession no.

P29275

UniProt accession no.

P29275

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ADORA2B(136)

General description

Anti-ADORA2B Antibody detects endogenous levels of total ADORA2B protein.
ADORA2B (adenosine A2b receptor) is a G-protein coupled receptor. It is the most adenosine insensitive adenosine receptor. This gene is located on human chromosome 17p12-p11.2. Anti-ADORA2B Antibody detects endogenous levels of total ADORA2B protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human ADORA2B.

Immunogen Range: 231-280

Biochem/physiol Actions

ADORA2B (adenosine A2b receptor) acts as a therapeutic target for cancer treatment. The tumor cells can use A2b receptor to induce tumor progression. ADORA2B controls immune cell activity. It plays a major role in the transcriptional induction and protein stability of protein period 2 (Per2).

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia.
Eckle T, et al.
Nature Medicine, 18(5), 774-774 (2012)
CD73-Dependent Generation of Adenosine and Endothelial Adora2b Signaling Attenuate Diabetic Nephropathy.
Eunyoung T, et al.
Journal of the American Society of Nephrology, 25 (3), 547-563 (2014)
Role of adenosine A2b receptor overexpression in tumor progression.
Sepulveda C, et al.
Life Sciences, 166, 92-99 (2016)
Pharmacogenetics of asthma.
Fenech A and Hall IP
British Journal of Clinical Pharmacology, 53(1), 3-15 (2002)
The A2b adenosine receptor antagonist PSB-603 promotes oxidative phosphorylation and ROS production in colorectal cancer cells via adenosine receptor-independent mechanism.
M?lck C, et al.
Cancer Letters, 383(1), 135-143 (2016)

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