Dipeptidyl peptidase 4 (DPP4), also known as cluster of differentiation 26 (CD26), is localized on T- cell surface and interacts with adenosine deaminase (ADA), collagen and CD459. The gene encoding this protein is localized on human chromosome 2q24.2.
Immunogen
Peptide with sequence C-PPHFDKSKKYP from the internal region of the protein sequence according to NP_001926.2.
Biochem/physiol Actions
Dipeptidyl peptidase 4 (DPP4) or CD26 plays a vital role in T cell co-stimulation, cell-to-cell adhesion and in human immunodeficiency virus (HIV) infection. It functions as a serine protease enzyme that catalyzes the cleavage of dipeptides from peptides containing proline or alanine residues. This protein is a biomarker and therapeutic target for asthma. Deletion of the DPP4 gene affects carbohydrate metabolism which in turn leads to mental retardation and hypotonia. Abnormal expression of the protein is observed during liver regeneration, cirrhosis and liver tumorigenesis. Also, DPP4 level is reduced in serum of chronic obstructive pulmonary disease (COPD) patients.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Dipeptidyl peptidase-4 is highly expressed in bronchial epithelial cells of untreated asthma and it increases cell proliferation along with fibronectin production in airway constitutive cells.
Shiobara T
Respiratory Research (2016)
Genomic organization, exact localization, and tissue expression of the human CD26 (dipeptidyl peptidase IV) gene.
Abbott CA
Immunogenetics (1994)
Expression and Clinical Significance of Serum Dipeptidyl Peptidase IV Chronic Obstructive Pulmonary Disease.
Chang XY
The American Journal of the Medical Sciences (2016)
Intestinal crypts have great capacity for repair and regeneration after intestinal stem cell (ISC) injury. Here, we define the cellular remodeling process resulting from ISC niche interruption by transient Notch pathway inhibition in adult mice. Although ISCs were retained, lineage
Molecular analyses of human and rat dipeptidyl peptidase IV.
Abbott CA
Advances in Experimental Medicine and Biology (1997)
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