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Key Documents

COO/COA

SAB2500067

Anti-Amphiphysin/AMPH antibody produced in goat

Name: Anti-Amphiphysin/AMPH antibody produced in goat
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-AMPH1, Anti-HGNC:471

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About This Item

MDL number:

MFCD01633026

UNSPSC Code:

12352203

NACRES:

NA.41

biological source

goat

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, rat, canine, mouse

technique(s)

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

P49418

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... AMPH(273)

General description

AMPH (Amphiphysin) is a 128kD peripheral protein highly distributed in nervous system including many neurons, certain endocrine cell types, and spermatocytes. It exists as two isoforms having different molecular weights 128 and 108kD respectively, in breast cancer. In human, it is located on chromosome 7, region p13-p14. It is a member of amphiphysin family and consists of an SH3 domain.

Immunogen

Peptide with sequence C-KRKDESRISKAE from the internal region of the protein sequence according to NP_001626.1; NP_647477.1.

Application

Anti-Amphiphysin/AMPH antibody produced in goat is suitable for western blot.

Biochem/physiol Actions

AMPH (Amphiphysin) is involved in several pleotropic functions including endocytosis, actin function, and cell growth control. It plays an important role in synaptic vesicle endocytosis of axon terminals. Alteration in AMPH gene is associated with heritable disorders of the nervous system, endocrine tissues and male fertility. It also has correlation with a rare neurologic autoimmune disease, paraneoplastic Stiff-Man syndrome. It is also involved in the neoplastic growth cone dynamics.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Pictograms

GHS07

Signal Word

Warning

Hazard Statements

H315,H319

Precautionary Statements

P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Expression of amphiphysin I, an autoantigen of paraneoplastic neurological syndromes, in breast cancer.

S Floyd et al.

Molecular medicine (Cambridge, Mass.), 4(1), 29-39 (1998-03-26)

Amphiphysin I is a 128 kD protein highly concentrated in nerve terminals, where it has a putative role in endocytosis. It is a dominant autoantigen in patients with stiff-man syndrome associated with breast cancer, as well as in other paraneoplastic

Primary structure of human amphiphysin, the dominant autoantigen of paraneoplastic stiff-man syndrome, and mapping of its gene (AMPH) to chromosome 7p13-p14.

R Yamamoto et al.

Human molecular genetics, 4(2), 265-268 (1995-02-01)

Amphiphysin is a protein peripherally associated with synaptic vesicles. It is expressed in many neurons, certain endocrine cell types, and spermatocytes. Autoantibodies against amphiphysin occur in patients afflicted with a rare neurologic autoimmune disease, paraneoplastic Stiff-Man syndrome. To provide a

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