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SAB2102031

Sigma-Aldrich

Anti-RNF31 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-FLJ10111, Anti-FLJ23501, Anti-MGC19975, Anti-Ring finger protein 31, Anti-ZIBRA

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

mol wt

120 kDa

species reactivity

rabbit, guinea pig, rat, human

packaging

pkg of 100 μL buffered aqueous solution
pkg of 50 μg lyophilized powder

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

UniProt accession no.

Q96EP0

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RNF31(55072)

Immunogen

Synthetic peptide directed towards the middle region of human RNF31

Application

Anti-RNF31 antibody produced in rabbit has been used in immunoblotting and immunoprecipitation.

Biochem/physiol Actions

PWP2 contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions.The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions.

Sequence

Synthetic peptide located within the following region: SLINAHSLDPATLYEVEELETATERYLHVRPQPLAGEDPPAYQARLLQKL

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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SPATA2 links CYLD to the TNF-? receptor signaling complex and modulates the receptor signaling outcomes.
Wagner SA
The Embo Journal, 35(17), 1868-1884 (2016)
Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.
Nakazawa S
Nature Communications, 7:12547, 1-14 (2016)
Kouki Hoshino et al.
Scientific reports, 14(1), 346-346 (2024-01-04)
RNF31 is a multifunctional RING finger protein implicated in various inflammatory diseases and cancers. It functions as a core component of the linear ubiquitin chain assembly complex (LUBAC), which activates the nuclear factor kappaB (NF-κB) pathway via the generation of
Seshiru Nakazawa et al.
Nature communications, 7, 12547-12547 (2016-08-25)
Optineurin (OPTN) mutations cause neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and glaucoma. Although the ALS-associated E478G mutation in the UBAN domain of OPTN reportedly abolishes its NF-κB suppressive activity, the precise molecular basis in ALS pathogenesis still remains unclear.
Structural and functional analyses of DNA-sensing and immune activation by human cGAS.
Kato K
PLoS ONE, 8(10), 1-9 (2013)
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