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Key Documents

R8782

Sigma-Aldrich

Ro4368554

≥98% (HPLC)

Synonym(s):

3-benzenesulfonyl-7-(4-methyl-piperazin-1-yl)-1H-indole, 7-(4-methyl-1-piperazinyl)-3-(phenylsulfonyl)-1H-Indole

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About This Item

Empirical Formula (Hill Notation):
C19H21N3O2S
CAS Number:
Molecular Weight:
355.45
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
Pricing and availability is not currently available.

Assay

≥98% (HPLC)

form

powder

color

off-white

solubility

DMSO: >10 mg/mL

originator

Roche

storage temp.

room temp

SMILES string

CN1CCN(CC1)c2cccc3c(c[nH]c23)S(=O)(=O)c4ccccc4

InChI

1S/C19H21N3O2S/c1-21-10-12-22(13-11-21)17-9-5-8-16-18(14-20-19(16)17)25(23,24)15-6-3-2-4-7-15/h2-9,14,20H,10-13H2,1H3

InChI key

AOPYPEADLGTXRA-UHFFFAOYSA-N

Biochem/physiol Actions

Ro4368554 is a 5-HT6 receptor antagonist.
Ro4368554 is a 5-HT6 receptor antagonist. RO4368554 acts selectively at 5-HT6 receptors where it binds with a greater than 100-fold selectivity over other monoamine receptor subtypes (-log M pKi = 9.4 at 5-HT6 and 7.1 at 5-HT2A).

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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