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R104

Sigma-Aldrich

Rauwolscine hydrochloride

powder

Synonym(s):

α-Yohimbine hydrochloride, 17α-Hydroxy-20α-yohimban-16 β-carboxylic acid methyl ester hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C21H26N2O3 · HCl
CAS Number:
6211-32-1
Molecular Weight:
390.90
EC Number:
228-279-6
MDL number:
MFCD06668052
UNSPSC Code:
12352200
PubChem Substance ID:
24277804
Pricing and availability is not currently available.

form

powder

optical activity

[α]25/D +52.13°, c = 1 in H2O

color

white to off-white

solubility

H2O: soluble

SMILES string

Cl.COC(=O)[C@@H]1[C@@H](O)CCC2CN3CCc4c([nH]c5ccccc45)C3CC12

Gene Information

human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , HTR1A(3350)

Biochem/physiol Actions

α2-adrenoceptor antagonist; 5-HT1A serotonin receptor agonist.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301 + H311 + H331

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
078K1502
107K1490
107K1489
027K0755
076K1086

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H De Vos et al.
European journal of pharmacology, 207(1), 1-8 (1991-05-25)
The alpha 2 adrenergic antagonist [3H]rauwolscine binds with comparable nanomolar affinity to alpha 2 adrenoceptors and the nonadrenergic 5-HT1A receptors sites in human frontal cortex membranes. Addition of 0.5 mM GTP into the incubation medium produces a significant decrease in
B D Perry et al.
European journal of pharmacology, 76(4), 461-464 (1981-12-17)
[3H]Rauwolscine, a specific and potent alpha 2-antagonist radioligand, was used to characterize alpha 2-receptor binding in bovine cerebral cortex. [3H]Rauwolscine binding was reversible, stereospecific, and saturable. Association, dissociation, and saturation studies revealed one site interactions (k -1/k+1 = 1.2 nM
Jing Yuan et al.
Nature chemical biology, 5(10), 765-771 (2009-09-08)
Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279 bioactive chemicals. Hundreds of compounds were
Bernd Jergas et al.
Naunyn-Schmiedeberg's archives of pharmacology, 387(7), 621-628 (2014-05-24)
The cannabinoid CB1 receptors on the noradrenergic neurons in guinea pig hippocampal slices show an endogenous endocannabinoid tone. This conclusion is based on rimonabant, the facilitatory effect of which on noradrenaline release might be due to its inverse CB1 receptor
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the

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