The product N7143 is intended for Research Use Only and does not have approvals from any agency for i.p. injections. Nigericin is soluble in DMSO up to 50 mg/mL and in ethanol up to 20 mg/mL, with stock solutions able to be stored for up to 3 months at -20 °C.
N7143
Nigericin sodium salt
≥98% (TLC)
Synonym(s):
Antibiotic K178, Antibiotic X464, Azalomycin M, Helexin C, Polyetherin A
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All Photos(4)
About This Item
Empirical Formula (Hill Notation):
C40H67NaO11
CAS Number:
Molecular Weight:
746.94
Beilstein:
3892398
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.
Recommended Products
biological source
Streptomyces hygroscopicus
Quality Level
Assay
≥98% (TLC)
form
powder
antibiotic activity spectrum
Gram-positive bacteria
Mode of action
cell membrane | interferes
storage temp.
2-8°C
SMILES string
[Na+].[H][C@@]1(CC[C@H](C)[C@@]([H])(O1)[C@@H](C)C([O-])=O)C[C@]2([H])C[C@@H](OC)[C@@H](C)[C@]3(O2)O[C@@](C)(C[C@H]3C)[C@@]4([H])CC[C@](C)(O4)[C@]5([H])O[C@]([H])(C[C@@H]5C)[C@@]6([H])O[C@@](O)(CO)[C@H](C)C[C@@H]6C
InChI
1S/C40H68O11.Na/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34;/h21-35,41,44H,11-20H2,1-10H3,(H,42,43);/q;+1/p-1/t21-,22-,23-,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34-,35+,37-,38-,39-,40+;/m0./s1
InChI key
MOYOTUKECQMGHE-PDEFJWSRSA-M
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General description
Chemical structure: polyether
Nigericin, a polyether ionophore, serves as a probe of ion transport across mitochondrial membranes.[1] It catalyzes the overall electroneutral exchange of K+ for H+(1) and acts as a potassium efflux activator. It may enhance bactericidal action via inflammasome-independent mechanisms specific to NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3).[2] Nigericin is a linear molecule with rings of heterocyclic oxygen together with a hydroxyl group. In the membrane, the molecule cyclizes to form a structure like valinomycin. Nigericin forms a neutral complex while losing a proton when it binds a cation which can diffuse across the membrane as a mobile carrier. Nigericin in protonated noncomplexed form is also considered mobile.
Application
Biochem/physiol Actions
Polyether ionophore that disrupts membrane potential and stimulates ATPase activity in mitochondria. Ion selectivity is K+> Rb+≥ Cs+>> Na+.
Other Notes
As ion-selective electrode - an efficient K+-carrier.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Has nigericin been tested or approved for intraperitoneal (i.p.) injection in mice?also advice on the safety of nigericin injection into mice and recommended solvents for its use.
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