NOTCH homolog-1 (NOTCH-1) is a transmembrane receptor.
Immunogen
synthetic peptide corresponding to residues 2170-2187 of human NOTCH1.
Biochem/physiol Actions
NOTCH homolog-1 (NOTCH-1) is an integral part of the NOTCH signaling pathway, which regulates various cellular functions. NOTCH-1 enhances the invasion of cancer cells and mutations in the gene encoding it have been associated with chronic lymphocytic leukemia (CLL).
Physical form
solution in phosphate buffered saline, containing 0.02% sodium azide.
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International journal of cancer, 138(1), 195-205 (2015-07-15)
Dysregulation of the Notch1 receptor has been shown to facilitate the development and progression of colorectal cancer (CRC) and has been identified as an independent predictor of disease progression and worse survival. Although mutations in the NOTCH1 receptor have not
International journal of clinical and experimental pathology, 8(3), 2737-2745 (2015-06-06)
We aimed to investigate the role of Notch1/Hes signaling pathway in the pathogenesis of abnormal ossification of hip ligament in patients with ankylosing spondylitis (AS). 22 AS patients scheduled for artificial hip arthroplasty were randomly chosen as AS group. As
NOTCH1 mutations occur in approximately 10% of patients with chronic lymphocytic leukemia (CLL). However, the relationship between the genetic aberrations and tumor cell drug resistance or disease progression remains unclear. Frameshift deletions were detected by gene sequencing in the NOTCH1
Notch 1 is a key component of the Notch pathway, which performs a crucial role in clear cell renal cell carcinoma (CCRCC) development. The present study aimed to investigate whether Notch 1 could serve as a potential target for CCRCC
OncoTargets and therapy, 12, 7663-7674 (2019-10-02)
The Notch signaling pathway plays an oncogenic role in tongue squamous cell carcinoma. The aim of this study was to inhibit the proliferation and self-renewal of tongue cancer cells by applying Notch signaling pathway inhibitor FLI-06 (Selleck, USA) and to
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