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M5199

Sigma-Aldrich

Meldonium dihydrate

≥98% (HPLC), powder

Synonym(s):

MET 88, Quaterin

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About This Item

Empirical Formula (Hill Notation):
C6H14N2O2 · 2H2O
CAS Number:
86426-17-7
Molecular Weight:
182.22
MDL number:
MFCD00876389
UNSPSC Code:
12352200
PubChem Substance ID:
329818003
NACRES:
NA.77
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Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to off-white

solubility

H2O: >40 mg/mL

storage temp.

2-8°C

SMILES string

C[N+](C)(C)NCCC([O-])=O

InChI

1S/C6H14N2O2/c1-8(2,3)7-5-4-6(9)10/h7H,4-5H2,1-3H3

InChI key

PVBQYTCFVWZSJK-UHFFFAOYSA-N

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Application

Meldonium dihydrate has been used as an anti-ischemic agent to evaluate its protective effects on Ischemia-reperfusion (I/R) in chick embryos.[1]

Biochem/physiol Actions

Meldonium exhibits anti-ischemic activity and shows therapeutic effects against cerebral and cardiac ischemic disorders.[2]
Meldonium is an Inhibitor of γ-butyrobetaine hydroxylase (BBOX) a key enzyme in the synthesis of carnitine.
Meldonium is an inhibitor of γ-butyrobetaine hydroxylase (BBOX).

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000236338
0000236338
0000238061
0000054998
0000054999

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Meldonium: Pharmacological, toxicological, and analytical aspects
Berlato D G and Bairros A
Toxicological Research, 4 (2020)
Eram Fauzia et al.
Frontiers in pharmacology, 9, 1034-1034 (2018-10-10)
Ischemia-reperfusion (I/R)-related disorders, such as stroke, myocardial infarction, and peripheral vascular disease, are among the most frequent causes of disease and death. Tissue injury or death may result from the initial ischemic insult, primarily determined by the magnitude and duration
Sylwia Magiera et al.
Journal of AOAC International, 97(6), 1526-1537 (2015-01-30)
A rapid and sensitive ultra-HPLC/MSIMS (UHPLC/MSIMS) assay method for the simultaneous determination in human urine of 22 drugs belonging to different pharmaceutical groups was developed. The drugs were extracted from urine samples and then separated on a Zorbax Rapid Resolution

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