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M1555

Sigma-Aldrich

MAHMA NONOate

Synonym(s):

6-(2-Hydroxy-1-methyl-2-nitrosohydrazino)-N-methyl-1-hexanamine, NOC-9

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About This Item

Empirical Formula (Hill Notation):
C8H20N4O2
CAS Number:
146724-86-9
Molecular Weight:
204.27
MDL number:
MFCD01310509
UNSPSC Code:
12352106
PubChem Substance ID:
24896668
NACRES:
NA.25

shipped in

dry ice

storage temp.

−70°C

SMILES string

[H][N+]([H])(C)CCCCCCN(C)N([O-])N=O

InChI

1S/C8H19N4O2/c1-9-7-5-3-4-6-8-11(2)12(14)10-13/h9H,3-8H2,1-2H3/q-1/p+1

InChI key

WASRCWNCCFPNEJ-UHFFFAOYSA-O

Application

NO donor

Biochem/physiol Actions

NO release: t1/2 = 3 min (phosphate buffer at 22° C)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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A M Vincent et al.
Journal of neurobiology, 40(2), 171-184 (1999-07-21)
Neuronal injury is intricately linked to the activation of three distinct neuronal endonucleases. Since these endonucleases are exquisitely pH dependent, we investigated in primary rat hippocampal neurons the role of intracellular pH (pH(i)) regulation during nitric oxide (NO)-induced toxicity. Neuronal
Zhao Zhong Chong et al.
Current neurovascular research, 2(3), 197-211 (2005-09-27)
Metabotropic glutamate receptors (mGluRs) are expressed throughout the mammalian central nervous system and integrate a host of signal transduction pathways that determine cellular function, plasticity and injury. Yet, one of the more unique regulatory functions of this family of GTP-binding
Mauricio Di Fulvio et al.
American journal of physiology. Heart and circulatory physiology, 284(5), H1686-H1692 (2003-01-11)
Nitric oxide (NO) donors regulate KCl cotransport (KCC) activity and cotransporter-1 and -3 (KCC1 and KCC3) mRNA expression in sheep erythrocytes and in primary cultures of rat vascular smooth muscle cells (VSMCs), respectively. In this study, we used NONOates as
J F Leikert et al.
FEBS letters, 506(2), 131-134 (2001-10-10)
4,5-Diaminofluorescein (DAF-2) and its membrane-permeable derivate DAF-2 diacetate are fluorescent probes that have been developed to perform real-time biological detection of nitric oxide (NO). Their use for intracellular imaging, however, has recently been seriously questioned and data using DAF-2 for
Francis A Sylvester et al.
American journal of physiology. Heart and circulatory physiology, 283(1), H353-H363 (2002-06-14)
Rats were fed a low-salt (LS; 0.4% NaCl) or high-salt (HS; 4.0% NaCl) diet for 3 days, and the responses of isolated cerebral arteries to acetylcholine (ACh), the nitric oxide (NO)-dependent dilator bradykinin, and the NO donor 6-(2-hydroxy-1-methyl-2-nitrosohydrazino)-N-methyl-1-hex-anamine (NOC-9) were
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