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B3436

Sigma-Aldrich

N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide

≥98% (HPLC), solid

Synonym(s):

C2-8

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About This Item

Empirical Formula (Hill Notation):
C19H14Br2N2O3S
CAS Number:
300670-16-0
Molecular Weight:
510.20
MDL number:
MFCD00355835
UNSPSC Code:
12352200
PubChem Substance ID:
24724418
NACRES:
NA.77

Assay

≥98% (HPLC)

form

solid

color

off-white

solubility

DMSO: ~20 mg/mL
H2O: insoluble

storage temp.

2-8°C

SMILES string

Brc1ccc(NC(=O)c2cccc(c2)S(=O)(=O)Nc3ccc(Br)cc3)cc1

InChI

1S/C19H14Br2N2O3S/c20-14-4-8-16(9-5-14)22-19(24)13-2-1-3-18(12-13)27(25,26)23-17-10-6-15(21)7-11-17/h1-12,23H,(H,22,24)

InChI key

SJJKUNDBFWUAQB-UHFFFAOYSA-N

Biochem/physiol Actions

N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide is the first inhibitor of aggregation of the polyglutamine (polyQ) sequence of the Huntington′s Disease protein (huntingtin); polyQ aggregation is neurotoxic, and inhibitors of aggregation may be therapeutic in HD and other polyQ diseases; C2-8 inhibited aggregation in HD PC12 cells with an IC50 of 50nM; when administered in food, suppressed neurodegeneration in vivo in the Drosophila HD model.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319,H413

Precautionary Statements

P273 - P305 + P351 + P338

Hazard Classifications

Aquatic Chronic 4 - Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Xiaoqian Zhang et al.
Proceedings of the National Academy of Sciences of the United States of America, 102(3), 892-897 (2005-01-12)
Polyglutamine (polyQ) disorders, including Huntington's disease (HD), are caused by expansion of polyQ-encoding repeats within otherwise unrelated gene products. In polyQ diseases, the pathology and death of affected neurons are associated with the accumulation of mutant proteins in insoluble aggregates.

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