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B1011

Sigma-Aldrich

Boc-Glu-Glu-Leu methyl ester

≥97% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C22H37N3O10
CAS Number:
Molecular Weight:
503.54
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26

Product Name

Boc-Glu-Glu-Leu methyl ester, ≥97% (HPLC)

Assay

≥97% (HPLC)

form

solid

storage temp.

−20°C

SMILES string

COC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)OC(C)(C)C

InChI

1S/C22H37N3O10/c1-12(2)11-15(20(32)34-6)24-18(30)13(7-9-16(26)27)23-19(31)14(8-10-17(28)29)25-21(33)35-22(3,4)5/h12-15H,7-11H2,1-6H3,(H,23,31)(H,24,30)(H,25,33)(H,26,27)(H,28,29)/t13-,14-,15-/m0/s1

InChI key

QJKPYQOKXLMHNY-KKUMJFAQSA-N

Biochem/physiol Actions

Boc-Glu-Glu-Leu methyl ester (Boc-Glu-Glu-Leu-OMe) is an N-terminal and C-terminal blocked derivative of the tripeptide L-Glu-LGlu-L-Leu.

Substrates

Possible substrate for Vitamin K-dependent carboxylation studies.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Vitamin K-dependent carboxylation.
P A Friedman et al.
The International journal of biochemistry, 19(1), 1-7 (1987-01-01)
R S Pottorf et al.
Journal of medicinal chemistry, 30(2), 445-448 (1987-02-01)
The synthesis of the amino acid sequence found in bovine prothrombin precursor 13-29 (PTP 13-29) has been achieved by solid-phase synthesis of the bis(acetamidomethyl)-protected linear peptide followed by cyclization to the monomeric disulfide. Synthesis of the disulfide bond was achieved
C Vermeer et al.
Haematologia, 18(2), 71-97 (1985-01-01)
Vitamin K-dependent carboxylase is found in the liver, where it is involved in the synthesis of four blood coagulation factors and protein C. The hepatic enzyme has partly been purified and several mechanisms have been postulated for the vitamin K-dependent

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