AC-0062A
CD61 (GPIIIa) (EP65) Rabbit Monoclonal Primary Antibody
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.
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biological source
rabbit
Quality Level
antibody form
Ig fraction of antiserum
clone
monoclonal
form
buffered aqueous solution
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:200
isotype
IgG
shipped in
wet ice
storage temp.
2-8°C
visualization
(membrane/cytoplasm)
General description
CD61, also known as GPIIIa and Integrin beta-3, is a glycoprotein encoded by the ITGB3 gene. CD61 heterodimerize with other cluster of differentiation molecules resulting in transmembrane integrins, facilitating cell to cell interactions and signal transduction. CD61 combines with CD41 to form platelet glycoprotein IIb/IIIa that serves as a receptor for fibrinogen and fibronectin. Platelet activation causes a conformational change in the glycoprotein to bind soluble fibrinogen to from a platelet plug. Alternative, CD61 can heterodimerize with CD51 to form Integrin alpha V beta 3, a receptor for vitronectin and von Willebrand factor. CD61 is expressed in the membrane and cytoplasm of platelets and megakaryocytes across diverse tissue types. Endothelium is also stained. Most cases of acute megakaryoblastic leukemia (AML M7) are positive for CD61.
Quality
 IVD |  IVD |  IVD |  RUO |
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Other Notes
For a copy of the IFU and CofA contact [email protected]
For Technical Service please contact: 800-665-7284 or email: [email protected]
For Technical Service please contact: 800-665-7284 or email: [email protected]
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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