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Key Documents

A3612

Sigma-Aldrich

Ceftizoxime sodium salt

Synonym(s):

Ceftizoxime sodium

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About This Item

Linear Formula:
C13H12N5NaO5S2
CAS Number:
68401-82-1
Molecular Weight:
405.38
UNSPSC Code:
51284149
NACRES:
NA.85
Pricing and availability is not currently available.

Assay

≥98% (HPLC)

form

solid

color

white to faint yellow

solubility

DMSO: 1 mg/mL

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

Mode of action

cell wall synthesis | interferes

storage temp.

−20°C

InChI

1S/C13H13N5O5S2.Na/c1-23-17-7(5-4-25-13(14)15-5)9(19)16-8-10(20)18-6(12(21)22)2-3-24-11(8)18;/h2,4,8,11H,3H2,1H3,(H2,14,15)(H,16,19)(H,21,22);/q;+1/p-1/b17-7-;/t8-,11-;/m1./s1

InChI key

ADLFUPFRVXCDMO-LIGXYSTNSA-M

Biochem/physiol Actions

Ceftizoxime is third generation cephalosporin effective against Gram-negative and Gram-positive bacteria. It binds penicillin-binding proteins (PBPs) and inhibits the bacterial cell wall synthesis.[1]

Packaging

50mg

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
072M4138V
14120705
108M4838V

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Ch Bharathi et al.
Journal of pharmaceutical and biomedical analysis, 43(2), 733-740 (2006-09-05)
Ceftizoxime sodium is a parenteral beta-lactamic antibacterial drug. In the synthesis of ceftizoxime sodium, eight process related impurities were detected in HPLC analysis. Pure impurities obtained by both synthesis and preparative HPLC were co-injected with ceftizoxime sample to confirm the
A Yotsuji et al.
Antimicrobial agents and chemotherapy, 32(12), 1848-1853 (1988-12-01)
The susceptibilities of 52 clinical isolates of Bacteroides fragilis to five monoanionic cephalosporins were examined. Cefoperazone showed the highest antibacterial activity, followed by ceftezole, cefazolin, cefamandole, and cephalothin. There were two groups of resistant strains: one group (ca. 15%), of
Athena Limnios et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 119(6), 356-363 (2011-05-17)
Antimicrobial resistance (AMR) in Neisseria gonorrhoeae remains a global public health problem. Susceptibility to first-line treatment extended-spectrum cephalosporins (ESCs) is decreasing worldwide resulting in therapeutic failures with oral ESCs. This study describes a cefpodoxime 10 μg disc test for screening
Okeoma Mmeje et al.
Sexually transmitted diseases, 39(9), 665-670 (2012-08-21)
Concurrent patient-partner treatment (CPPT) is the provision of treatment to the index patient and their sexual partner(s) and appears to be an effective method of preventing repeat sexually transmitted infections. The objectives of the study were to determine whether CPPT
Soraya Maria Zandim Maciel Dias Ferreira et al.
Bioorganic & medicinal chemistry letters, 22(14), 4605-4608 (2012-06-26)
Osteomyelitis is an infectious disease located in the bone or bone marrow. Long-circulating and pH-sensitive liposomes containing a technetium-99m-labeled antibiotic, ceftizoxime, (SpHL-(99m)Tc-CF) were developed to identify osteomyelitis foci. Biodistribution studies and scintigraphic images of bone infection or non infection-bearing rats
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