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A2033

Sigma-Aldrich

Alginic acid sodium salt from brown algae

Medium viscosity

Synonym(s):

Algin, Sodium alginate

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About This Item

CAS Number:
9005-38-3
MDL number:
MFCD00081310
UNSPSC Code:
12352201
NACRES:
NA.25
Pricing and availability is not currently available.

biological source

algae (brown)

Quality Level

200

form

powder

color

white to brown

viscosity

≥2,000 cP, 2 %(25 °C)

solubility

water: 10 mg/mL, slightly hazy to strongly hazy, faintly yellow to yellow

storage temp.

2-8°C

SMILES string

[Na+].[O-]C(=O)C1O[C@H]([C@H]([C@H]([C@@H]1O)O)O)O

InChI

1S/C6H10O7.Na/c7-1-2(8)4(5(10)11)13-6(12)3(1)9;/h1-4,6-9,12H,(H,10,11);/q;+1/p-1/t1-,2-,3-,4?,6+;/m0./s1

InChI key

MSXHSNHNTORCAW-MPGIDXPLSA-M

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Application

Alginate, a colloidal polyuronic acid structural molecule capable of gelation, is used in the preparation of colloidal biodegradable structures such as gels, biofilms, beads, nanoparticles, and microcapsules suitable for applications that range from gel based separation technologies to drug delivery and cell preservation.

Other Notes

A straight-chain, hydrophilic, colloidal, polyuronic acid composed of guluronic and mannuronic acid residues.
To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SLCN1893
SLCP2198
SLCM9527
SLCK5333
SLCK4085

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Chen Xu et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 106(1), 237-244 (2017-01-29)
Previous studies have shown that tricalcium silicate bone cements possess good bioactivity and appropriate degradation rate. However, they also showed some weaknesses such as poor washout resistance, formability and injectability, which have seriously hindered their clinical applications. The purpose of
Svetlana R Derkach et al.
Polymers, 13(5), 743-743 (2021-03-07)
Polyelectrolyte complexes of sodium alginate and gelatin obtained from cold-blooded fish were studied for potential application as structure-forming agents in food hydrogels. The mass ratio of sodium alginate to gelatin plays a decisive role in the sol-gel transition and rheological
Vijayaganapathy Vaithilingam et al.
Biomaterials, 32(33), 8416-8425 (2011-09-06)
Encapsulation of human islets may prevent their immune rejection when transplanted into diabetic recipients. To assist in understanding why clinical outcomes with encapsulated islets were not ideal, we examined the effect of encapsulation on their global gene (mRNA) and selected
Laura Ferlauto et al.
Frontiers in neuroscience, 12, 648-648 (2018-10-05)
Reducing the mechanical mismatch between the stiffness of a neural implant and the softness of the neural tissue is still an open challenge in neuroprosthetics. The emergence of conductive hydrogels in the last few years has considerably widened the spectrum
Jiwan K Chettri et al.
Fish & shellfish immunology, 93, 934-939 (2019-08-14)
Tightened regulations and an environmentally friendly approaches in fish production have greatly reduced the use of antibiotics but green solutions are continuously being explored. The use of functional feed may have a potential in the aquaculture sector in securing biomass
View All Related Papers

Questions

1–10 of 13 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. what is the viscosity?

    1 answer

    1. As listed in the 'PROPERTIES' section, the viscosity is ?2,000 cP. The exact value is listed on the lot specific Certificate of Analysis. Please navigate to the DOCUMENTATION section of the Product Detail Page to access a Certificate under ‘Certificate of Analysis’: https://www.sigmaaldrich.com/product/sigma/a2033#product-documentation

      Helpful?

  4. A2033 제품의 밀도를 알고 싶습니다 정확한 값까지는 아니어도 추정치 만이라도 알고 싶습니다

    1 answer

    1. Unfortunately, the density of this product is not determined internally. However, various external sources state that Sodium Alginate has a density of 1.0 g/cm3(Temp: 25 °C).

      Helpful?

  5. What is the average molecular weight of this product?

    1 answer

    1. The Molecular Weight of this product is approximately 200,000 daltons.

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  6. What is the purity and the loss on drying of the product A2033? Additionally, what is the ash content?

    1 answer

    1. The purity and loss on drying are not tested for alginic acid. Please see the link below to review the testing and specifications for this product: https://www.sigmaaldrich.com/specification-sheets/235/361/A2033-BULK________SIGMA____.pdf

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  7. How to sterilization this product without properties interference?

    1 answer

    1. Solutions may be filter-sterilized or autoclaved prior to the addition of cations (required for gelation). Note that extended autoclave times may be detrimental to bead formation.

      Helpful?

  8. Does this product create a low or high stiffness gel?

    1 answer

    1. This product is not tested for gelation or gel strength. Alginate forms a gel in the presence of cations. Typically CaCl2 is used to initiate gel formation. Increasing the concentration of calcium will result in a more firm gel. Calcium chloride may be added at a range of 0.1M to 0.5M, with gel strength increasing with the CaCl2 concentration.

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  9. What is the ratio of mannuronic acid to guluronic acid in this product (A2033)?

    1 answer

    1. The A2033 has a mannuronic acid to guluronic acid ratio of approximately 1.56. The mannuronic acid range is 60-70 % and guluronic acid range is 30-40 %.

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  10. what is the final product when alginate lyase act on sodium alginate in Tris-Hcl buffer system

    1 answer

    1. Alginate lyase is an enzyme that catalyzes the degradation of alginate, a polysaccharide found in brown algae. The resulting post-digest products would be oligosaccharides and monosaccharides. It is often used to reduce viscosity of alginate or de-encapsulate cells. See product A1603 for additional information on this enzyme.
      https://www.sigmaaldrich.com/product/sigma/a1603

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1–10 of 13 Questions  

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