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73361

Sigma-Aldrich

Bis[2-(N-succinimidyl-oxycarbonyloxy)ethyl] sulfone

≥97.0% (CHN)

Synonym(s):

BSOCOES

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About This Item

Empirical Formula (Hill Notation):
C14H16N2O12S
CAS Number:
57683-72-4
Molecular Weight:
436.35
Beilstein:
1521053
EC Number:
260-904-8
MDL number:
MFCD00047123
UNSPSC Code:
12352200
PubChem Substance ID:
57652476
Pricing and availability is not currently available.

Assay

≥97.0% (CHN)

reaction suitability

reagent type: cross-linking reagent

mp

169-173 °C

storage temp.

−20°C

SMILES string

O=C1CCC(=O)N1OC(=O)OCCS(=O)(=O)CCOC(=O)ON2C(=O)CCC2=O

InChI

1S/C14H16N2O12S/c17-9-1-2-10(18)15(9)27-13(21)25-5-7-29(23,24)8-6-26-14(22)28-16-11(19)3-4-12(16)20/h1-8H2

InChI key

XUDGDVPXDYGCTG-UHFFFAOYSA-N

Other Notes

Homobifunctional crosslinking reagent for proteins[1][2][3]; cross-linking reagents used as molecular rulers[4]

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
1436775V
1436775
448762/1

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J Shin et al.
The Journal of biological chemistry, 260(23), 12828-12831 (1985-10-15)
The electrophoretic mobility of radioiodinated follitropin (FSH) alpha and beta subunits as well as the alpha beta dimer changed markedly depending on the concentration of reducing agents such as dithiothreitol. The changes were more dramatic in the beta subunit than
R A Smith et al.
The Journal of biological chemistry, 261(21), 9850-9853 (1986-07-25)
The quaternary structural relationships between subunits of the follitropin (FSH) receptor were determined through the use of the reversible, homobifunctional, chemical cross-linking reagent bis[2-(succinimidooxycarbonyloxy)ethyl]sulfone (BSOCOES) after formation of covalent 125I-azidobenzoyl-FSH-receptor subunit complexes by photoaffinity labeling. This experimental approach resulted in
J Shin et al.
The Journal of biological chemistry, 260(23), 12822-12827 (1985-10-15)
Both of the alpha and beta subunits of intact human follitropin (FSH) were radioiodinated with 125I-sodium iodide and chloramine-T and could be resolved on sodium dodecyl sulfate-polyacrylamide gels. Radioiodinated FSH was affinity-cross-linked with a cleavable (nondisulfide) homobifunctional reagent to its
E Antonian et al.
European journal of biochemistry, 145(3), 511-517 (1984-12-17)
Calf brain plain synaptic vesicle proteins have been cross-linked with bis[2-(succinimidooxycarbonyloxy)ethyl] sulfone, a homobifunctional, cleavable reagent, as well as with N-hydroxysuccinimidyl 4-azidobenzoate, a photosensitive, heterobifunctional reagent. These results demonstrate the generality of a recent report that synaptic vesicle proteins can
H A Coppock et al.
The Biochemical journal, 318 ( Pt 1), 241-245 (1996-08-15)
We have previously demonstrated specific binding sites for adrenomedullin, a novel member of the calcitonin family of peptides, in rat muscles. It is unclear whether these receptors are vascular or muscular. Receptors for the structurally similar calcitonin gene-related peptide (CGRP)
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