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46946

Sigma-Aldrich

Fluorescein isothiocyanate–dextran

average mol wt 150,000, (FITC:Glucose = 1:160)

Synonym(s):

FITC-Dextran 150, FITC–Dextran

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About This Item

CAS Number:
60842-46-8
MDL number:
MFCD00131092
UNSPSC Code:
12352201
NACRES:
NA.32

form

solid

mol wt

average mol wt 150,000

composition

(FITC:Glucose = 1:160)

extent of labeling

~0.004 mol/mol FITC glucose

solubility

H2O: 25 mg/mL, slightly hazy, very deep yellow-orange

fluorescence

λex 492 nm; λem 518 nm in 0.1 M phosphate pH 8.0

storage temp.

2-8°C

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Application

Dextran labeled with fluorescein isothiocyanate for possible use in perfusion studies in animals.
Fluorescein isothiocyanate–dextran (FITC-Dextran 150) is use as a fluorescent probe to study cell permeability. FITC-Dextran 150 is useful to study processes that affect the permeability of the blood brain barrier (BBB) and microvascular structures. FITC-Dextran 150 is used in fluorescence microlymphography.

Other Notes

Commonly utilized as a macromolecular fluorochrome in inflammatory studies

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315 - H319 - H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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D M Gawlowski et al.
Microvascular research, 37(1), 1-15 (1989-01-01)
Fluorescein-labeled dextran MW 150K (FITC-Dx 150) is commonly utilized as a macromolecular fluorochrome in inflammatory studies. We examined the influence of FITC-Dx 150 on leukocyte activity as assessed by adherence to cheek pouch microvessels. Transcapillary exchange was evaluated as fluorochrome
Fátima Z G A Cyrino et al.
Clinical and experimental pharmacology & physiology, 31(3), 159-162 (2004-03-11)
1. The present study was designed to evaluate the effect of micronization on the protective effect of the purified flavonoid fraction (MPFF) on increases in macromolecular permeability induced by ischaemia-reperfusion in the hamster cheek pouch microcirculation. 2. Male hamsters (Mesocricetus
Neil Y C Lin et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(12), 5399-5404 (2019-03-06)
Three-dimensional renal tissues that emulate the cellular composition, geometry, and function of native kidney tissue would enable fundamental studies of filtration and reabsorption. Here, we have created 3D vascularized proximal tubule models composed of adjacent conduits that are lined with
Haruo Aramoto et al.
American journal of physiology. Heart and circulatory physiology, 287(4), H1590-H1598 (2004-05-25)
Vascular endothelial growth factor (VEGF) induces mild vasodilation and strong increases in microvascular permeability. Using intravital microscopy and digital integrated optical intensity image analysis, we tested, in the hamster cheek pouch microcirculation, the hypothesis that differential signaling pathways in arterioles
Takayuki Ishii et al.
Brain research, 1321, 164-168 (2010-01-26)
Ischemia-reperfusion injury is induced by recovery of blood flow after ischemia. This phenomenon is a main cause of ischemic brain injury. The integrity of the blood-brain barrier (BBB) fails after cerebral ischemia and reperfusion. Further elucidation of this phenomenon promotes
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