Skip to Content
Merck
All Photos(6)

Key Documents

View All Documentation

T4625

Sigma-Aldrich

Thiamine hydrochloride

reagent grade, ≥99% (HPLC)

Synonym(s):

Aneurine hydrochloride, Vitamin B1 hydrochloride

Sign Into View Organizational & Contract Pricing
All Photos(6)

About This Item

Empirical Formula (Hill Notation):
C12H17ClN4OS · HCl
CAS Number:
67-03-8
Molecular Weight:
337.27
Beilstein:
3851771
EC Number:
200-641-8
MDL number:
MFCD00012780
UNSPSC Code:
12352209
eCl@ss:
34058006
PubChem Substance ID:
24900057
NACRES:
NA.26
Pricing and availability is not currently available.

biological source

synthetic (organic)

Quality Level

200

grade

reagent grade

Assay

≥99% (HPLC)

form

powder

technique(s)

HPLC: suitable

color

white

mp

250 °C (dec.) (lit.)

solubility

H2O: 50 mg/mL, clear, colorless

SMILES string

CC1=NC(N)=C(C[N+]2=CSC(CCO)=C2C)C=N1.Cl.[Cl-]

InChI

1S/C12H17N4OS.2ClH/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;;/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);2*1H/q+1;;/p-1

InChI key

DPJRMOMPQZCRJU-UHFFFAOYSA-M

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

Thiamine is a water-soluble vitamin-B complex. Structurally, it possesses a five-membered thiazolium ring and a six-membered amino-pyrimidine ring connected by a methyl group. Thiamine is naturally available in fruits, vegetables, poultry, eggs.[1]

Application

Thiamine hydrochloride has been used as a vitamin supplement to the holidic medium[2] and in bacterial growth medium.[3][4]

Biochem/physiol Actions

Thiamine is an essential coenzyme in carbohydrate metabolism.[5] Deficiency of thiamine causes beriberi, a neurological and cardiovascular disease.[1] Thiamine is administered in case of deficiency, either due to reduced intake or synthesis.[5][1] Congenital defect in the thiamine transporter gene SLC19A2 causes thiamine-responsive megaloblastic anemia syndrome (TRMA). Thiamine mimics acetylcholine in brain and possible exerts a role in Alzheimer′s disease.[1] Thiamine deficiency in ruminants causes polioencephalomalacia.[5]

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000405609
0000389288
0000379785
0000379489
0000359024

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Real-time in vitro measurement of GTP hydrolysis
Shutes A and Der CJ
Methods, 37(2), 183-189 (2005)
Improved production of carotenes from synthetic medium by Blakeslea trispora in a bubble column reactor
Nanou K, et al.
Biochemical Engineering Journal, 67, 203-207 (2012)
Applied Pharmacology for Veterinary Technicians (2009)
A holidic medium for Drosophila melanogaster
Piper MDW, et al.
Nature Methods, 11(1), 100-100 (2013)
Clinical and biological aspects of thiamine deficiency
Vitamins in the prevention of human diseases (2011)
View All Related Papers

Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service