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70127

Sigma-Aldrich

Naloxone hydrochloride dihydrate

≥99.0% (TLC)

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About This Item

Empirical Formula (Hill Notation):
C19H21NO4 · HCl · 2H2O
CAS Number:
51481-60-8
Molecular Weight:
399.87
Beilstein:
6260807
EC Number:
201-447-6
MDL number:
MFCD00150901
UNSPSC Code:
12352202
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Assay

≥99.0% (TLC)

storage temp.

2-8°C

SMILES string

O.O.Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC=C

InChI

1S/C19H21NO4.ClH.2H2O/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;;;/h2-4,14,17,21,23H,1,5-10H2;1H;2*1H2/t14-,17+,18+,19-;;;/m1.../s1

InChI key

TXMZWEASFRBVKY-IOQDSZRYSA-N

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Application

Displaces morphine and other opiate agonists from the opiate receptor. In studies on the opiate receptor[1][2]

Other Notes

Potent opiate antagonist.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335,H413

Precautionary Statements

P261 - P305 + P351 + P338

Hazard Classifications

Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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C Mollereau et al.
The Journal of biological chemistry, 263(34), 18003-18008 (1988-12-05)
When assayed for specific opiate binding in the presence of 120 mM NaCl, digitonin extracts from frog (Rana ridibunda) brain membranes were found to contain about the same quantity (0.5 pmol/mg of protein) of high (Kdh = 0.4 nM) and
T Costa et al.
Proceedings of the National Academy of Sciences of the United States of America, 86(19), 7321-7325 (1989-10-01)
According to classical models of drug-receptor interactions, competitive antagonists share with agonists the ability to bind to a common site on the receptor molecule. However, they are different from agonists, as they cannot trigger the "stimulus" that leads to biological
Naloxone in the refractory neonatal septic shock.
M Radicioni et al.
Minerva pediatrica, 65(1), 122-123 (2013-02-21)
Yumei Liu et al.
PloS one, 8(1), e51573-e51573 (2013-02-06)
Previously, we demonstrated that electroacupuncture (EA) decreased lymphocyte infiltration into the spinal cords of rats presenting with experimental autoimmune encephalomyelitis (EAE), a disease model used in the study of multiple sclerosis (MS). The aim of this study was to characterize
Sarah Bowman et al.
The American journal of medicine, 126(7), 565-571 (2013-05-15)
Addiction to prescription opioids is prevalent in primary care settings. Increasing prescription opioid use is largely responsible for a parallel increase in overdose nationally. Many patients most at risk for addiction and overdose come into regular contact with primary care
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