GCM2 is a nuclear protein that is involved in transcription regulation of many genes including ones important in parathyroid metabolism and development. Glial cells missing homolog 2 or GCM2 is expressed predominately in the pharyngeal pouches and, at later stages, in the developing and mature parathyroid glands. In humans, loss of GCM2 function, either through recessive apomorphic mutations or dominant inhibitor mutations in the human GCM2 gene, leads to isolated hypoparathyroidism. GCM2 expression is continued in the adult parathyroid at high levels and appears to be important in calcium sensing and calcium receptor expression in adult parathyroid cells.
Immunogen
GST-tagged recombinant protein corresponding to Human GCM2.
Application
Research Category Neuroscience
Research Sub Category Developmental Neuroscience
This Anti-GCM2 Antibody, clone 8A10.1 is validated for use in Western Blotting for the detection of GCM2.
Quality
Evaluated by Western Blotting in SH-SY5Y cell lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected GCM2 in 10 µg of SH-SY5Y cell lysate.
Target description
~ 58 kDa observed. An uncharacterized band appears at ~110 kDa in some lysates.
Physical form
Format: Purified
Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Certificates of Analysis (COA)
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