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MAB4343

Sigma-Aldrich

Anti-SOX-2 Antibody

clone 6F1.2, Chemicon®, from mouse

Synonym(s):

Anti-ANOP3, Anti-MCOPS3

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

6F1.2, monoclonal

species reactivity

mouse, human

packaging

antibody small pack of 25 μg

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

input

sample type: mouse embryonic stem cell(s)
sample type neural stem cell(s)
sample type: human embryonic stem cell(s)
sample type induced pluripotent stem cell(s)

isotype

IgG2b

NCBI accession no.

NM_003106.2

UniProt accession no.

P48431

shipped in

ambient

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... SOX2(6657)
mouse ... Sox2(20674)

Related Categories

General description

Sox-2 plays a key role in embryonic stem cell development, and has been shown to help stem cells maintain pluripotent potential. It has also been shown to be associated with uncommitted dividing stem cell and precursor cells of the developing CNS.

Immunogen

Recombinant GST Fusion protein.

Application

Anti-SOX-2 Antibody detects level of SOX-2 & has been published & validated for use in IC, IH & WB.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors

Quality

Tested

Target description

~34 kDa

Physical form

Format: Purified
Purified Immunoglobulin by protein A affinity chromatography and presented as a liquid in 0.02 M phosphate buffer, pH 7.6, with 0.25 M NaCl. Contains 0.1% sodium azide.

Storage and Stability

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Masoumeh Fakhr Taha et al.
BioMed research international, 2014, 941486-941486 (2014-08-26)
The expression pattern of pluripotency markers in adipose tissue-derived stem cells (ADSCs) is a subject of controversy. Moreover, there is no data about the signaling molecules that regulate these markers in ADSCs. In the present study, we studied the roles
Weixiang Guo et al.
Nature protocols, 7(11), 2005-2012 (2012-10-20)
In adult mammals, the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone of the dentate gyrus (DG) show ongoing neurogenesis, and multipotent neural stem or progenitor cells (NSCs) in these two regions exhibit different intrinsic properties. However
High-content imaging-based screening of microenvironment-induced changes to stem cells.
Vega, SL; Liu, E; Patel, PJ; Kulesa, AB; Carlson, AL; Ma, Y; Becker, ML; Moghe, PV
Journal of Biomolecular Screening null
Valentina Poletti et al.
PloS one, 10(5), e0126590-e0126590 (2015-05-16)
Genome-wide mapping of transcriptional regulatory elements is an essential tool for understanding the molecular events orchestrating self-renewal, commitment and differentiation of stem cells. We combined high-throughput identification of transcription start sites with genome-wide profiling of histones modifications to map active
Ying Li et al.
Scientific reports, 6, 38665-38665 (2016-12-08)
Notch1 signaling plays a critical role in maintaining and determining neural stem/progenitor cell (NSPC) fate, yet the transcriptional mechanism controlling Notch1 specific expression in NSPCs remains incomplete. Here, we show transcription factor Nkx6.1 interacts with a cis-element (CR2, an evolutionarily
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