5.08150

LY 344864 Hydrochloride

• Synonym(s): LY 344864 Hydrochloride, 5-HT _1F Serotonin Receptor Agonist, LY 344864, LY344864, LY-344864, 5-HT_1F Serotonin Receptor Agonist, LY 344864, LY344864, LY-344864
• Empirical Formula (Hill Notation): C₂₁H₂₂FN₃O · xHCl
• CAS Number: 186544-26-3
• Molecular Weight: 351.42 (free base basis)
• UNSPSC Code: 12352200

Properties

• Assay: ≥98% (HPLC)
• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: water: 10 mM; DMSO: 100 mM
• storage temp.: 2-8°C
• InChI: 1S/C21H22FN3O.ClH/c1-25(2)16-8-10-20-18(12-16)17-11-15(7-9-19(17)24-20)23-21(26)13-3-5-14(22)6-4-13;/h3-7,9,11,16,24H,8,10,12H2,1-2H3,(H,23,26);1H/t16-;/m1./s1
• InChI key: OKUHLSYESBLBCP-PKLMIRHRSA-N

Description

General description

A selective, brain penetrant, full agonist for the 5-HT_1F receptor (pKi = 8.2). It possesses little affinity for the 56 other serotonergic and non-serotonergic neuronal binding sites examined. When examined for its ability to inhibit forskolin-induced cyclic AMP accumulation in cells stably transfected with human 5-HT_1F receptors, LY344864 was shown to be a full agonist producing an effect similar in magnitude to serotonin itself. Suitable for both in vitro and in vivo applications and its effects are often reversed with the 5-HT_1B/1D antagonist GR 127935 (Cat. No. 508014)

Biochem/physiol Actions

Primary Target
5-HT_1F

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Amrutkar, D. V. et al. 2012. Pain.153, 830.

Phebus, L. A. et al. 1997. Life Sci.61, 2117.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable