06-944
Anti-TPOR/c-Mpl Antibody
Upstate®, from rabbit
Synonym(s):
Anti-C-MPL, Anti-MPLV, Anti-THCYT2, Anti-THPOR, Anti-TPOR
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse, human
manufacturer/tradename
Upstate®
technique(s)
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... MPL(4352)
mouse ... Mpl(17480)
Specificity
glycosylated and unglycosylated TPO receptor/c-Mpl
Immunogen
KLH-conjugated, synthetic peptide corresponding to amino acids 615-628 of human TPO (thrombopoietin) receptor (C-ANHSYLPLSYWQQP)
Application
Anti-TPOR/c-Mpl Antibody is an antibody against TPOR/c-Mpl for use in IP, WB, IH.
Research Category
Signaling
Signaling
Research Sub Category
Growth Factors & Receptors
Growth Factors & Receptors
Quality
routinely evaluated by immunoblot on RIPA lysates from DAMI cells
Target description
68.5 kDa (calculated)
Physical form
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Format: Purified
Protein A chromatography
Storage and Stability
2 years at -20°C
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Certificates of Analysis (COA)
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Norma E Fox et al.
Experimental hematology, 37(4), 495-503 (2009-03-24)
To genetically and functionally characterize mutations of c-Mpl that lead to thrombocytopenia in a child with congenital amegakaryocytic thrombocytopenia. We identified two c-Mpl mutations in a child with clinical features of congenital amegakaryocytic thrombocytopenia, one a previously described mutation in
Cédric Cleyrat et al.
Traffic (Copenhagen, Denmark), 15(9), 961-982 (2014-06-17)
Myeloproliferative neoplasms (MPNs) are often characterized by JAK2 or calreticulin (CALR) mutations, indicating aberrant trafficking in pathogenesis. This study focuses on Mpl trafficking and Jak2 association using two model systems: human erythroleukemia cells (HEL; JAK2V617F) and K562 myeloid leukemia cells
Reiji Nozaki et al.
Hepatology research : the official journal of the Japan Society of Hepatology, 43(6), 610-620 (2012-11-20)
Liver cirrhosis (LC) is the end stage of chronic liver disease. No definitive pharmacological treatment is currently available. We previously reported that thrombopoietin (TPO) promoted liver regeneration and improved liver cirrhosis by increasing platelet count. TPO is therefore considered to
A R Moliterno et al.
Blood, 94(8), 2555-2561 (1999-10-09)
Recently, we demonstrated a marked reduction in the expression of the thrombopoietin receptor, Mpl, in polycythemia vera (PV) platelets and megakaryocytes using an antiserum against the Mpl extracellular domain. To further examine this abnormality, we raised an antibody to the
Melanie Märklin et al.
Journal of cellular and molecular medicine, 24(21), 12491-12503 (2020-09-22)
Thrombocyte formation from megakaryocyte and their progenitor cells is tightly regulated by thrombopoietin (TPO) and its receptor c-MPL, thereby maintaining physiological functionality and numbers of circulating platelets. In patients, dysfunction of this regulation could cause thrombocytopenia or myeloproliferative syndromes. Since
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