21 residue synthetic peptide (KTSPPRPRPGPTGPRELTEHE) corresponding to the c-terminus of rat KA2 with a lysine added to the n-terminus
Application
Anti-KA2/GRIK5 (Kainate Receptor) Antibody is an antibody against KA2/GRIK5 (Kainate Receptor) for use in IC, IH, IP & WB.
Research Category Neuroscience
Research Sub Category Neurochemistry & Neurotrophins
Neurodegenerative Diseases
Quality
routinely evaluated by immunoblot on rat brain microsomal preparation
Target description
123kDa
Physical form
Format: Purified
Protein G Chromatography
of 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Storage and Stability
2 years at -20°C
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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The mechanism of kainate receptor targeting and clustering is still unresolved. Here, we demonstrate that members of the SAP90/PSD-95 family colocalize and associate with kainate receptors. SAP90 and SAP102 coimmunoprecipitate with both KA2 and GluR6, but only SAP97 coimmunoprecipitates with
Regulation of surface insertion and internalization of AMPA and NMDA receptors has emerged as a key mechanism for the control of synaptic strength. Regulatory elements for synaptic kainate receptors (KARs) are, however, largely undetermined. We have found that SNAP25 is
The Journal of biological chemistry, 276(19), 16092-16099 (2001-03-30)
Recent studies have demonstrated that kainate receptors are associated with members of the SAP90/PSD-95 family (synapse-associated proteins (SAPs)) in neurons and that SAP90 can cluster and modify the electrophysiological properties of GluR6/KA2 kainate receptors when co-expressed in transfected cells. In
Functional cooperation between KA2 and GluR6 subunits is involved in the ischemic brain injury.
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