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999994P

Avanti

12:0 Diether PC

Avanti Research™ - A Croda Brand 999994P, powder

Synonym(s):

1,2-di-0-dodecyl-sn-glycero-3-phosphocholine

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About This Item

Empirical Formula (Hill Notation):
C32H68NO6P
CAS Number:
72593-72-7
Molecular Weight:
593.86
UNSPSC Code:
51191904
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 10 mg (999994P-10mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 999994P

lipid type

cardiolipins
phospholipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OCCCCCCCCCCCC)COCCCCCCCCCCCC)=O

General description

12:0 Diether PC (phosphocholine) is a glycerophospholipid having choline as the alcohol moiety, attached to the phosphate group. It has two dodecane chains attached to the sn-1 and sn-2 positions of the glycerol backbone by ether bonds.

Application

12:0 Diether PC or 1,2-di-O-dodecyl-sn-glycero-3-phosphocholine might be used in small micelles to study the interaction of peptides with model membranes by nuclear magnetic resonance (NMR) experiments.

Biochem/physiol Actions

12:0 Diether PC (phosphocholine) is useful in bicelles formation. Bicelles are suitable to be integrated into standard crystallization protocols and in contrast to micelles, bicelles maintain the protein in a more native bilayer environment allowing proteins to be captured in a more biologically relevant orientation. It is found to be a simpler membrane model and is highly compatible with nuclear magnetic resonance (NMR).

Packaging

5 mL Amber Glass Screw Cap Vial (999994P-10mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Certificates of Analysis (COA)

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Interaction of a peptide derived from C-terminus of human TRPA1 channel with model membranes mimicking the inner leaflet of the plasma membrane
Witschas K, et al.
Biochimica et Biophysica Acta - Biomembranes, 1848(5), 1147-1156 (2015)
Structural and functional roles of ether lipids
Dean JM and Lodhi IJ
Protein & cell, 9(2), 196-206 (2018)

Articles

Critical Micelle Concentrations (CMCs) - Avanti® Polar Lipids

The critical micelle concentration (CMC) can be approximately defined as the lipid monomer concentration at which appreciable amounts (>5% of total) of micellar aggregates first begin to appear in the equilibrium: nM1<=>Mn

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