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850092P

Avanti

Brain Lyso PS

Avanti Research™ - A Croda Brand 850092P, powder

Synonym(s):

L-α-lysophosphatidylserine (Brain, Porcine) (sodium salt)

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About This Item

CAS Number:
383907-66-2
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (LPS; may contain up to 10% of the 2-LPS isomer, TLC)

form

powder

packaging

pkg of 1 × 10 mg (850092P-10mg)
pkg of 1 × 5 mg (850092P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 850092P

lipid type

phosphoglycerides

shipped in

dry ice

storage temp.

−20°C

SMILES string

O[C@](COP([O-])(OC[C@](C([O-])=O)([H])[NH3+])=O)([H])COC(CCCCCCCCCCCCCCCCC)=O.[Na+]

General description

Lyso-phosphatidylserine (lyso-PS) is produced by the enzymatic action of phospholipase A1 and A2 on phosphatidylserine.

Application

Brain Lyso PS is suitable for use:
  • as standard to quantify lipids using ultra high performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UHPLC-ESI-MS/MS)
  • in the preparation of liposomes for coating dynabeads for binding of factor H (fH)
  • as a ligand for G-protein coupled receptor 34 (GPR34) in in vitro experiments to investigate its effect granulosa cells(GC) and hormone production
  • as substrate for sicariid phospholipase D (PLD) toxins (SicTox) enzymes

Biochem/physiol Actions

Lyso-Phosphatidylserine (Lyso-PS) plays a key role in histamine release from mast cells. Lyso-PS inhibits the growth to T cells. It is a chemotactic substance for fibroblast and tumor cells. Lyso-PS is involved in tumor progression and allergic reactions.

Packaging

5 mL Amber Glass Screw Cap Vial (850092P-10mg)
5 mL Amber Glass Screw Cap Vial (850092P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ultra-high-performance liquid chromatography electrospray ionization tandem mass spectrometry for accurate analysis of glycerophospholipids and sphingolipids in drug resistance tumor cells
Li L, et al.
Journal of Chromatography A, 1381(3), 140-148 (2015)
Annexin-II, DNA, and histones serve as factor H ligands on the surface of apoptotic cells
Leffler J, et al.
Test, 285(6), 3766-3776 (2010)
Lysophosphatidylserine stimulates chemotactic migration of colorectal cancer cells through GPR34 and PI3K/Akt pathway
Iida Y, et al.
Anticancer Research, 34(10), 5465-5472 (2014)
Altered immune response in mice deficient for the G protein-coupled receptor GPR34
Liebscher I, et al.
Test, 286(3), 2101-2110 (2011)
G protein-coupled receptor 34 in ovarian granulosa cells of cattle: changes during follicular development and potential functional implications
Spicer LJ, et al.
Domestic Animal Endocrinology, 59(6), 90-99 (2017)
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