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Key Documents

797901

Sigma-Aldrich

Ultrastable fluorescent silica nanobeads

25 nm, lyophilized

Synonym(s):

Fluorescent beads, Fluorescent nanoparticles, Silica nanoparticles

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About This Item

Linear Formula:
SiO2
Molecular Weight:
60.08
UNSPSC Code:
12352302
NACRES:
NA.23
Pricing and availability is not currently available.

Quality Level

100

form

powder

particle size

25 nm

fluorescence

λem 590 nm

UV absorption

λ: 570 nm Amax

storage temp.

2-8°C

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Application

The use of labeling or staining agents has greatly assisted the study of complex biological interactions in biology and the fluorescent labeling of biomolecules has been demonstrated as an indispensable tool in many biological studies. By virtue of excellent fluorescence properties the silica nanobeads find application in biological labeling; bioimaging; biosensing etc.[1][2] Ultrastable particles exhibit a very high resistance to photobleaching and can be used in single-particle imaging as well as in super resolution techniques such as stimulated emission depletion (STED) microscopy.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCW6820
MKCS7648
MKCP6479
MKCN0035
MKCK9897

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Geometrical confinement of quantum dots in porous nanobeads with ultraefficient fluorescence for cell-specific targeting and bioimaging
P-J Chen, S-H Hu, W-T Hung, S-Y Chen, and D-M Liu,
Journal of Materials Chemistry, 22(19), 9568-9575 (2012)
Luminescent nanomaterials for biological labelling
F. Wang, W. B. Tan, Y. Zhang, et al.
Nanotechnology, 17(1), R1-R13 (2006)

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Questions

1–2 of 2 Questions  

  1. Are these PFA-fixable?

    1 answer

    1. A specific PFA Fixation study is not performed on this material. The literature around this topic seems to suggest this is a possible use for this product and more details can be found below.

      Chiou AE, Hinckley JA, Khaitan R, Varsano N, Wang J, Malarkey HF 5th, Hernandez CJ, Williams RM, Estroff LA, Weiner S, Addadi L, Wiesner UB, Fischbach C. Fluorescent Silica Nanoparticles to Label Metastatic Tumor Cells in Mineralized Bone Microenvironments. Small. 2021 Apr;17(15):e2001432. doi: 10.1002/smll.202001432. Epub 2020 May 28. PMID: 32462807; PMCID: PMC7704907.

      Further application information can be found on the website through the link below.

      https://www.sigmaaldrich.com/technical-documents/technical-article/materials-science-and-engineering/biosensors-and-imaging/fluorescent-silica-nanobeads

      Helpful?

  2. what is dispersibility of this beads in water.

    1 answer

    1. The nanopowder may be re-dispersed by adding water directly to the storage vial. It is recommended to add 1 mL of water per each 1 mg of nanoparticles to be re-dispersed, and probe sonicating on ice for 8 minutes at 30% amplitude or until the powder has completely re-dissolved.

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