69520
5-Methyltryptamine hydrochloride
≥97.0% (AT)
Synonym(s):
3-(2-Aminoethyl)-5-methylindole hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C11H14N2 · HCl
CAS Number:
Molecular Weight:
210.70
Beilstein:
3707780
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
Assay
≥97.0% (AT)
mp
290-292 °C
SMILES string
Cl[H].Cc1ccc2[nH]cc(CCN)c2c1
InChI
1S/C11H14N2.ClH/c1-8-2-3-11-10(6-8)9(4-5-12)7-13-11;/h2-3,6-7,13H,4-5,12H2,1H3;1H
InChI key
RBHDFGBPJGEYCK-UHFFFAOYSA-N
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Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Characterization of eight biogenic indoleamines as substrates for type A and type B monoamine oxidase.
O Suzuki et al.
Biochemical pharmacology, 30(11), 1353-1358 (1981-06-01)
O A Candia et al.
Biochimica et biophysica acta, 602(2), 389-400 (1980-11-04)
The effects of serotonin and five other indoles were tested on the electrical parameters and ionic transport in the isolated toad lens. Serotonin, tryptophan and 5-hydroxy-L-tryptophan did not affect the electrical parameters of the lens at concentrations as high as
I Litosch et al.
The Journal of biological chemistry, 261(2), 638-643 (1986-01-15)
Incubation of blowfly salivary gland homogenates with 30 microM [gamma-32P]ATP resulted in a rapid, Mg2+-dependent, synthesis of [32P]polyphosphoinositides and [32P]phosphatidic acid. 5-Methyltryptamine, in the presence of 10 microM guanosine 5'-(3-O-thio)trisphosphate, reduced the net accumulation of 32P label into phosphatidylinositol-4,5-P2 and
M A Wallace et al.
The Journal of pharmacology and experimental therapeutics, 255(3), 1296-1300 (1990-12-01)
Stimulation of phosphoinositide-specific phospholipase C (PLC) by muscarinic cholinergic and serotoninergic agonists was measured in rat brain cortical membranes by using exogenously supplied substrates. Serotonin, tryptamine, 5-fluorotryptamine and 5-methyltryptamine stimulated PLC with EC50 values of 1.7, 11.2, 15.0, and 29.4
J Sallés et al.
Psychopharmacology, 154(2), 115-125 (2001-04-21)
One of the major pathways for neurotransmitter signaling involves phosphoinositide-specific and G-protein-dependent phospholipase C-beta (PLC-beta), which stimulates the formation of inositol 1,4,5-trisphosphate and diacylglycerol. Serotonergic and muscarinic-cholinergic signals in the brain are largely mediated through the hydrolysis of phosphoinositides by
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