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Sigma-Aldrich

tert-Butyldimethylsilyl cyanide

97%

Synonym(s):

tert-Butyl-cyano-dimethylsilane

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About This Item

Linear Formula:
(CH3)3CSi(CH3)2CN
CAS Number:
56522-24-8
Molecular Weight:
141.29
Beilstein:
2234709
MDL number:
MFCD00054923
UNSPSC Code:
12352100
PubChem Substance ID:
24865490
NACRES:
NA.22

Assay

97%

mp

76-79 °C (lit.)

SMILES string

CC(C)(C)[Si](C)(C)C#N

InChI

1S/C7H15NSi/c1-7(2,3)9(4,5)6-8/h1-5H3

InChI key

CWAKIXKDPQTVTA-UHFFFAOYSA-N

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General description

tert-Butyldimethylsilyl cyanide (TBDMSCN) is a bulkier trialkylsilylcyanide. It participates in the cyanosilylation of enantiopure 4-oxoazetidine-2-carbaldehydes. Addition of TBDMSCN to sterically hindered ketones in the presence of Lewis acid or base catalyst has been studied. ZnI2-catalyzed addition of TBDSCN to 2,2-dimethylcyclohexanone, 2,2,6-trimethylcyclohexanone and 2,2,6,6-tetramethylcyclohexanone affords protected cyanohydrins.

Application

tert-Butyldimethylsilyl cyanide may be used as reagent for the formation of β-isonitrile alcohols via epoxides.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301 + H311 + H331

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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The Journal of Organic Chemistry, 51, 5010-5010 (1986)
P(RNCH2CH2)N: efficient catalysts for the cyanosilylation of aldehydes and ketones.
Fetterly BM and Verkade JG.
Tetrahedron Letters, 46(46), 8061-8066 (2005)
Benito Alcaide et al.
The Journal of organic chemistry, 72(21), 7980-7991 (2007-09-18)
The cyanosilylation of enantiopure 4-oxoazetidine-2-carbaldehydes with tert-butyldimethylsilyl cyanide was promoted by either molecular sieves or catalytic amount of sodium carbonate to give O-silylated beta-lactam cyanohydrins with good yield and diastereoselectivity. In contrast, Lewis acids did not effectively promote the cyanosilylation
Addition of tert-butyldimethyl-or tert-butyldiphenylsilyl cyanide to hindered ketones.
Golinski M, et al.
The Journal of Organic Chemistry, 58(1), 159-164 (1993)

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