Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine's rewarding effects but preserves natural reward processing.

Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine's rewarding effects but preserves natural reward processing.

Science advances (2021-10-21)

Andry Andrianarivelo, Estefani Saint-Jour, Paula Pousinha, Sebastian P Fernandez, Anna Petitbon, Veronique De Smedt-Peyrusse, Nicolas Heck, Vanesa Ortiz, Marie-Charlotte Allichon, Vincent Kappès, Sandrine Betuing, Roman Walle, Ying Zhu, Charlène Joséphine, Alexis-Pierre Bemelmans, Gustavo Turecki, Naguib Mechawar, Jonathan A Javitch, Jocelyne Caboche, Pierre Trifilieff, Jacques Barik, Peter Vanhoutte

PMID34669474

RESUMEN

[Figure: see text].

MATERIALES

Referencia del producto

Marca

Descripción del producto

D2944

Sigma-Aldrich

Anti-D₁ Dopamine Receptor antibody,Rat monoclonal, clone 1-1-F11 s.E6, purified from hybridoma cell culture

ABN462

Sigma-Aldrich

Anticuerpo anti-receptor D2 de dopamina, from rabbit, purified by affinity chromatography

05-432

Sigma-Aldrich

Anticuerpo anti-NR1, CT., Upstate^®, from mouse

MAB5782

Sigma-Aldrich

Anticuerpo anti-NMDAR2B, NT, ascites fluid, clone 1A8.9B3, Chemicon^®