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Merck

1118000

USP

Chloroquine phosphate

United States Pharmacopeia (USP) Reference Standard

Sinónimos:

Chloroquine diphosphate salt, N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt

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About This Item

Fórmula empírica (notación de Hill):
C18H26ClN3 · 2H3PO4
Número de CAS:
Peso molecular:
515.86
Beilstein/REAXYS Number:
4223142
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

biological source

synthetic

grade

pharmaceutical primary standard

agency

USP

vapor pressure

<0.0000001 kPa ( 25 °C)

API family

chloroquine

form

powder

packaging

pkg of 500 mg

manufacturer/tradename

USP

storage condition

protect from light

color

yellow

pH

3.5-4.5 (10% in aqueous solution, pH <6.0)

mp

200 °C (dec.) (lit.)

solubility

water: 50 g/L
benzene: practically insoluble
chloroform: practically insoluble
ethanol: practically insoluble
ether: practically insoluble

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

OP(O)(O)=O.OP(O)(O)=O.CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12

InChI

1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4)

InChI key

QKICWELGRMTQCR-UHFFFAOYSA-N

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General description

Chloroquine Phosphate is a salt of chloroquine, a 9-aminoquinoline drug that effectively inhibits viral infections in humans.

Application

Chloroquine phosphate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Amodiaquine Hydrochloride
  • Amodiaquine Hydrochloride Tablets
  • Chloroquine
  • Chloroquine Phosphate
  • Chloroquine Phosphate Compounded Oral Suspension
  • Chloroquine Phosphate Tablets

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Determination of chloroquine and its decomposition products in various brands of different dosage forms by liquid chromatography
Abdelrahman AN, et al.
Journal of Pharmaceutical and Biomedical Analysis, 12(2), 205-208 (1994)
Zilong Wang et al.
Brain : a journal of neurology, 144(2), 665-681 (2020-12-29)
Opioids such as morphine are mainstay treatments for clinical pain conditions. Itch is a common side effect of opioids, particularly as a result of epidural or intrathecal administration. Recent progress has advanced our understanding of itch circuits in the spinal
Chloroquine is a potent inhibitor of SARS coronavirus infection and spread
Vincent MJ, et al.
Virology Journal, 2(1), 1-10 (2005)
Chloroquine Phosphate USP Monograph
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 39(3), 959-959 (2020)
Cecilia Pessoa Rodrigues et al.
Nature communications, 12(1), 6212-6212 (2021-10-29)
Noncommunicable diseases (NCDs) account for over 70% of deaths world-wide. Previous work has linked NCDs such as type 2 diabetes (T2D) to disruption of chromatin regulators. However, the exact molecular origins of these chronic conditions remain elusive. Here, we identify

Protocolos

Chloroquine Phosphate HPLC Assay meets system suitability criteria with good resolution, reproducibility, and sensitivity.

Chloroquine Phosphate HPLC Assay meets system suitability criteria with good resolution, reproducibility, and sensitivity.

Chloroquine Phosphate HPLC Assay meets system suitability criteria with good resolution, reproducibility, and sensitivity.

Chloroquine Phosphate HPLC Assay meets system suitability criteria with good resolution, reproducibility, and sensitivity.

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