T3766
Thymine 1-β-D-arabinofuranoside
≥99%
Sinónimos:
araT, 1-β-D-Arabinofuranosylthymine
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About This Item
Fórmula empírica (notación de Hill):
C10H14N2O6
Número de CAS:
Peso molecular:
258.23
EC Number:
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
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Productos recomendados
Quality Level
assay
≥99%
form
powder
optical activity
[α]20/D 90°, c = 5 mg/mL in water
solubility
0.5 M HCl: 20 mg/mL, clear, colorless
storage temp.
2-8°C
SMILES string
CC1=CN(C2OC(CO)C(O)C2O)C(=O)NC1=O
InChI
1S/C10H14N2O6/c1-4-2-12(10(17)11-8(4)16)9-7(15)6(14)5(3-13)18-9/h2,5-7,9,13-15H,3H2,1H3,(H,11,16,17)
InChI key
DWRXFEITVBNRMK-UHFFFAOYSA-N
Application
1-β-D-Arabinofuranosylthymine (araT):
- maybe used as a substrate and inhibitor to study the specificity and kinetics of thymidine kinase(s), such as herpes simplex virus type 1 and 2 thymidine kinases, the HSV1-tk and, HSV2-tk gene products.
- is used to study the specificity and kinetics of various mitochondrial nucleoside kinases.
- has been used as an antiviral agent to study its efficacy on Cryptosporidium parvum in vitro.[1]
Storage Class
11 - Combustible Solids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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J Balzarinia et al.
Biochemical pharmacology, 61(6), 727-732 (2001-03-27)
Introduction of a bulky lipophilic acyl entity at the 2'-OH position of both 1-beta-D-arabinofuranosylthymine (araT) and (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU), consistently resulted in a marked ( approximately 10-fold) increase in the inhibitory activity of these new arabinosyl nucleoside analogues for the mitochondrial
N Solaroli et al.
Antiviral research, 79(2), 128-132 (2008-05-06)
The thymidine kinases from feline herpesvirus (FHV TK) and canine herpesvirus (CHV TK) were cloned and characterized. The two proteins are closely sequence-related to each other and also to the herpes simplex virus type 1 thymidine kinase (HSV-1 TK). Although
Alex McAvoy et al.
PLoS computational biology, 11(8), e1004349-e1004349 (2015-08-27)
Evolutionary game theory is a powerful framework for studying evolution in populations of interacting individuals. A common assumption in evolutionary game theory is that interactions are symmetric, which means that the players are distinguished by only their strategies. In nature
Efficacy of select antivirals against Cryptosporidium parvum in vitro
Woods KM and Upton SJ
FEMS Microbiology Letters, 168(1), 59-63 (1998)
Xiuyun Wang et al.
Nature communications, 11(1), 653-653 (2020-02-02)
The industrial synthesis of ammonia (NH3) using iron-based Haber-Bosch catalyst requires harsh reaction conditions. Developing advanced catalysts that perform well at mild conditions (<400 °C, <2 MPa) for industrial application is a long-term goal. Here we report a Co-N-C catalyst with high
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