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Merck
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Key Documents

SRP3284

Sigma-Aldrich

GASP-1 human

recombinant, expressed in CHO cells, ≥95% (SDS-PAGE), ≥95% (HPLC)

Sinónimos:

GDF-associated serum protein-1

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

recombinant

expressed in CHO cells

assay

≥95% (HPLC)
≥95% (SDS-PAGE)

form

lyophilized

mol wt

55.0-66.0 kDa

packaging

pkg of 25 μg

concentration

0.0025-0.0040 μg/mL

impurities

<0.1 EU/μg endotoxin, tested

color

white to off-white

UniProt accession no.

Q8TEU8

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... WFIKKN2(124857)

General description

Growth and differentiation factor-associated serum protein-1 (GASP-1) is expressed primarily in the ovary, testis, and brain. The GASP-1 gene encodes a 571 amino acid protein that contains a 29 amino acid secretion signal sequence, and multiple identifiable structural features, including a WAP domain, a follistatin/Kazal domain, an immunoglobulin domain, two tandem Kunitz domains, and a netrin domain. Recombinant human GASP-1 is a 542 amino acid protein that migrates at an apparent molecular weight of approximately 55-66kDa by SDS-PAGE analysis under non-reducing conditions.

Biochem/physiol Actions

Growth and differentiation factor-associated serum protein-1 (GASP-1) is a secreted inhibitory TGF-β binding protein that contains multiple protease inhibitor structural domains. It can act as a potent soluble inhibitor of myostatin and GDF-11, but not Activin-A.

Physical form

Lyophilized from 10 mM Sodium Phosphate, pH 7.8.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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GASP/WFIKKN Proteins: Evolutionary Aspects of Their Functions
Olivier Monestier
PLoS ONE, 7(8), e43710-e43710 (2012)
Extracellular Regulation of Myostatin: A Molecular Rheostat for Muscle Mass
Se-Jin Lee
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry, 10, 183-194 (2011)
Jennifer J Hill et al.
Molecular endocrinology (Baltimore, Md.), 17(6), 1144-1154 (2003-02-22)
Myostatin, a member of the TGFbeta superfamily, is a potent and specific negative regulator of skeletal muscle mass. In serum, myostatin circulates as part of a latent complex containing myostatin propeptide and/or follistatin-related gene (FLRG). Here, we report the identification

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