SML1887

APX2009

≥98% (HPLC)

• Sinónimos: (2E)-2-[(3-methoxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methylidene]-N,N-diethylpentanamide, 2-[(1,4-Dihydro-3-methoxy-1,4-dioxo-2-naphthalenyl)methylene]-N,N-diethyl-pentanamide
• Fórmula empírica (notación de Hill): C₂₁H₂₅NO₄
• Número de CAS: 1415030-15-7
• Peso molecular: 355.43
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: white to beige
• solubilidad: DMSO: 10 mg/mL, clear
• temp. de almacenamiento: 2-8°C
• cadena SMILES: O=C1C(OC)=C(/C=C(CCC)/C(N(CC)CC)=O)C(C2=C1C=CC=C2)=O
• InChI: 1S/C21H25NO4/c1-5-10-14(21(25)22(6-2)7-3)13-17-18(23)15-11-8-9-12-16(15)19(24)20(17)26-4/h8-9,11-13H,5-7,10H2,1-4H3/b14-13+
• Clave InChI: WEMXCNYTFZUFSB-BUHFOSPRSA-N

Descripción

Acciones bioquímicas o fisiológicas

APX2009 is a cell penetrant potent and selective second-generation inhibitor of APE1 redox-signaling that stimulates APE1 DNA repair activity. APX2009 is neuroprotective against cisplatin and oxaliplatin induced toxicity. APX2009 exhibits potent antitumor activity in neuroblastoma cell lines and 3D spheroid pancreatic tumor model.

Cell penetrant potent and selective second-generation inhibitor of APE1 redox-signaling that stimulates APE1 DNA repair activity

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable