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SML1220

Sigma-Aldrich

Doripenem hydrate

≥98% (HPLC)

Sinónimos:

(4R,5S,6S)-3-[[(3S,5S)-5-[[(Aminosulfonyl)amino]methyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid hydrate

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About This Item

Fórmula empírica (notación de Hill):
C15H24N4O6S2 · H2O
Número de CAS:
364622-82-2
Peso molecular:
438.52
MDL number:
MFCD09749887
UNSPSC Code:
12352200
PubChem Substance ID:
329825727
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

InChI

1S/C15H24N4O6S2.H2O/c1-6-11-10(7(2)20)14(21)19(11)12(15(22)23)13(6)26-9-3-8(17-5-9)4-18-27(16,24)25;/h6-11,17-18,20H,3-5H2,1-2H3,(H,22,23)(H2,16,24,25);1H2/t6-,7-,8+,9+,10-,11-;/m1./s1

InChI key

NTUBEBXBDGKBTJ-WGLOMNHJSA-N

Biochem/physiol Actions

Doripenem hydrate is used to treat complicated urinary infection including Pyelonephritis caused by E.coli. Doripenem hydrate is promoted in the United States as DORIBAX®. This drug is synthesized from p-nitrobenzyl-protected enolphosphate 2b and N-(p-nitrobenzyloxycarbonyl)-protected aminomethylpyrrolidine.
Doripenem is an ultra-broad spectrum carbopenem antibiotic. Doripenem is active against both gram-positive and gram-negative bacteria.

Legal Information

DORIBAX is a registered trademark of Shionogi Inc.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Practical large-scale synthesis of doripenem: A novel 1β-methylcarbapenem antibiotic.
Nishino Y, et al.
Organic Process Research & Development, 7(6), 846-850 (2003)
Improved Large-scale One-pot Synthesis of Pure Doripenem Hydrate (S-4661).
Raju K R, et al.
Organic Prep. and Proc. Int., 48(4), 342-349 (2016)
Lokender Kumar et al.
Frontiers in microbiology, 12, 598498-598498 (2021-02-16)
Pseudomonas aeruginosa utilizes the quorum sensing (QS) system to strategically coordinate virulence and biofilm formation. Targeting QS pathways may be a potential anti-infective approach to treat P. aeruginosa infections. In the present study, we define cephalosporins' anti-QS activity using Chromobacterium

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