SML0362

NPS2143 hydrochloride

≥98% (HPLC)

• Sinónimos: 2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]-benzonitrile hydrochloride (1:1), NPS-2143 hydrochloride, SB-262470-A hydrochloride
• Fórmula empírica (notación de Hill): C₂₄H₂₅ClN₂O₂ · HCl
• Número de CAS: 324523-20-8
• Peso molecular: 445.38
• Número MDL: MFCD16038896
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825364
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• actividad óptica: [α]20/D +20 to +24°, c = 1.0 in methanol
• condiciones de almacenamiento: desiccated
• color: white to beige
• solubilidad: DMSO: >10 mg/mL
• temp. de almacenamiento: 2-8°C
• cadena SMILES: Cl.CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc3cccc(Cl)c3C#N
• InChI: 1S/C24H25ClN2O2.ClH/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26;/h3-12,20,27-28H,13,15-16H2,1-2H3;1H/t20-;/m1./s1
• Clave InChI: ZEBNDUQLNGYBNL-VEIFNGETSA-N

Descripción

Aplicación

NPS2143 hydrochloride has been used to study the function of calcium-sensing receptor :

• In the regulation of intestinal calcium transport.
• In the regulation of local negative feedback of intestinal calcium absorption.
• In sensorimotor decision making during development.

Acciones bioquímicas o fisiológicas

NPS2143 is a phenylalkylamine calcilytic compound, and might be useful in treating autosomal dominant hypocalcemia. It serves as a blocking agent for hERG (human ether-a-go-go-related gene ) channel, CYP2D6 (cytochrome P450 2D6 ) and monoamine transporters.

NPS2143 is a selective calcium-sensing receptor (CaR) antagonist.

NPS2143 is a selective calcium-sensing receptor (CaR) antagonist. The compound blocks increases in cytoplasmic calcium concentrations with an IC₅₀ of 43 nM, and stimulates parathyroid hormone (PTH) secretion from bovine parathyroid cells over a wide range of extracellular calcuim concentrations.

Información de seguridad

• Pictogramas: GHS07,GHS09
• Palabra de señalización: Warning
• Frases de peligro: H302 + H312 + H332,H410
• Consejos de prudencia: P261 - P273 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
• Clasificaciones de peligro: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable