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SML0320

Sigma-Aldrich

FR180204

≥98% (HPLC)

Sinónimos:

5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine, 5-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-amine, FR 180204

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About This Item

Fórmula empírica (notación de Hill):
C18H13N7
Número de CAS:
865362-74-9
Peso molecular:
327.34
Número MDL:
MFCD14585805
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
329825325
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Ensayo

≥98% (HPLC)

Formulario

powder

color

faintly yellow to dark yellow

solubilidad

DMSO: ≥10 mg/mL

temp. de almacenamiento

2-8°C

cadena SMILES

Nc1n[nH]c2nnc(cc12)-c3c(nn4ccccc34)-c5ccccc5

InChI

1S/C18H13N7/c19-17-12-10-13(20-22-18(12)23-21-17)15-14-8-4-5-9-25(14)24-16(15)11-6-2-1-3-7-11/h1-10H,(H3,19,21,22,23)

Clave InChI

XVECMUKVOMUNLE-UHFFFAOYSA-N

Categorías relacionadas

Aplicación

FR180204 has been used as ERK inhibitor:
  • to block extracellular-signal-regulated kinase (ERK) in order to validate whether homeobox B7 (HOXB7) regulates the migration and proliferation process via AKT/mitogen-activated protein kinases (MAPK) signaling[1]
  • of extracellular-signal-regulated kinase (ERK) to study the effects of signaling pathway inhibitors on differentiation and cell traction stress[2]
  • to determine if phosphorylation of this signaling protein is essential for mesenchymal stromal cell (MSC) derived therapeutic efficacy[3]

Acciones bioquímicas o fisiológicas

FR180204 is a potent, cell-permeable, ATP-competitive inhibitor of ERK1 and ERK2 (mitogen-activated protein kinase (MAPK)/extracellular-signal-regulated kinases (ERK) 1/2).
FR180204 is a potent, selective, cell-permeable, ATP-competitive inhibitor of ERK1 and ERK2.
It can be used to study the roles of ERK as well as for drug development.[4]

Características y beneficios

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
0000391910
0000391911
0000302342
0000391911
0000391910

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Sigma-Aldrich

P215

PD 98,059

LY-294,002 hydrochloride solid, ≥98% (HPLC)

Sigma-Aldrich

L9908

LY-294,002 hydrochloride

U0126 U0126 is a elective inhibitor of MEK-1 and MEK-2; weak inhibitor of PKC, Raf, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, Abl, Cdk2 and Cdk4.

Sigma-Aldrich

19-147

U0126

Gefitinib ≥98% (HPLC)

Sigma-Aldrich

SML1657

Gefitinib

SB 203580 solid, ≥98% (HPLC)

Sigma-Aldrich

S8307

SB 203580

Substrate stiffness and matrix composition coordinately control the differentiation of liver progenitor cells
Kourouklis AP, et al.
Biomaterials, 99, 82-94 (2016)
The TLR4-PAR1 Axis Regulates Bone Marrow Mesenchymal Stromal Cell Survival and Therapeutic Capacity in Experimental Bacterial Pneumonia
Gupta N, et al.
Stem Cells, 36(5), 796-806 (2018)
Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex
Ohori M, et al.
Biochemical and biophysical research communications, 336(1), 357-363 (2005)
Miho Tanaka et al.
Cancer research, 78(13), 3589-3603 (2018-04-25)
Natural killer (NK) cells express receptors specific for MHC class I (MHC-I) molecules involved in "missing-self" recognition of cancer and virus-infected cells. Here we elucidate the role of MHC-I-independent NKR-P1B:Clr-b interactions in the detection of oncogenic transformation by NK cells.
Mario Sechi et al.
Scientific reports, 8(1), 15726-15726 (2018-10-26)
The anti-proliferative activity of dietary flavonoid fisetin has been validated in various cancer models. Establishing its precise mechanism of action has proved somewhat challenging given the multiplicity of its targets. We demonstrated that YB-1 promotes epithelial-to-mesenchymal transition and its inhibition
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