SML0057

Camostat mesylate

≥98% (HPLC)

• Sinónimos: 4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic acid 2-(dimethylamino)-2-oxoethyl ester methanesulfonate; FOY 305; FOY-S 980; Foipan mesylate
• Fórmula empírica (notación de Hill): C₂₀H₂₂N₄O₅·CH₃SO₃H
• Número de CAS: 59721-29-8
• Peso molecular: 494.52
• Número MDL: MFCD00941410
• Código UNSPSC: 12352203
• ID de la sustancia en PubChem: 329825123
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: white to tan
• solubilidad: H₂O: ≥24 mg/mL
• emisor: Novartis
• temp. de almacenamiento: 2-8°C
• cadena SMILES: CS(O)(=O)=O.CN(C)C(=O)COC(=O)Cc1ccc(OC(=O)c2ccc(NC(N)=N)cc2)cc1
• InChI: 1S/C20H22N4O5.CH4O3S/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22;1-5(2,3)4/h3-10H,11-12H2,1-2H3,(H4,21,22,23);1H3,(H,2,3,4)
• Clave InChI: FSEKIHNIDBATFG-UHFFFAOYSA-N

Descripción

Aplicación

Camostat mesylate has been used to determine the effect of transmembrane protease, serine (TMPRSS) family proteases on cell-cell fusion.[1]

Camostat mesylate may be used in cell signaling studies.

Acciones bioquímicas o fisiológicas

Camostat is a serine protease inhibitor, airway epithelial sodium channel (ENaC) attenuator.

Camostat is a synthetic, orally bioavailble serine protease inhibitor and airway epithelial sodium channel (ENaC) attenuator.

Camostat mesylate (CM) is used to treat pancreatitis and reflux esophagitis after gastrectomy.[2]

Camostat mesylate inhibits the production of TNF-α and monocyte chemoattractant protein-1 (MCP-1) by monocytes. It also inhibits the activity of pancreatic stellate cells. Camostat mesylate regulates the cytokine expression and inflammation and is effective in the treatment of dibutyltin dichloride-induced rat pancreatic fibrosis.[2]

Características y beneficios

This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictogramas: GHS07,GHS09
• Palabra de señalización: Warning
• Frases de peligro: H315,H319,H335,H400
• Consejos de prudencia: P261 - P264 - P271 - P273 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable