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RAB1122

Sigma-Aldrich

Mouse EPO ELISA Kit

for cell culture supernatants, plasma, and serum samples

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About This Item

UNSPSC Code:
41116158
NACRES:
NA.32

species reactivity

mouse

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable

input

sample type cell culture supernatant(s)
sample type plasma
sample type serum sample(s)

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 1.5 pg/ml

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

mouse ... Epo(13856)

General description

This ELISA antibody pair detects Mouse Erythropoietin (EPO)

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

Biochem/physiol Actions

Erythropoietin (EPO) is a glycoprotein hormone which is essential for the proliferation of erythropoietic progenitors to produce red blood cells (RBCs). Peritubular fibroblast in kidney cortex is the primary site for EPO production in adults, though spleen, bone marrow and liver contribute to the production. In fetus, liver is the primary site for EPO production. Additionally, EPO functions in some cytoprotective activities like, antiapoptotic, antioxidant, and anti-inflammatory responses. Hypoxia inducible factors upregulate EPO expression. EPO expression increases with decreased hemoglobin concentration in few cases of anemia. Decreased production of EPO is the cause of anemia in chronic kidney diseases. Circulating endogenous antibodies to EPO (anti-EPO) is the cause of anemia in multiple diseases like human immunodeficiency virus (HIV) infection, hepatitis C virus infection, systemic lupus erythematosus. Gain-of-function polymorphism in EPO causes familial erythrocytosis.

Other Notes

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.

pictograms

Corrosion
GHS05

signalword

Warning

hcodes

H290

Hazard Classifications

Met. Corr. 1

Storage Class

8A - Combustible corrosive hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Physiology and pharmacology of erythropoietin
Jelkmann W
Transfusion Medicine and Hemotherapy : Offizielles Organ der Deutschen Gesellschaft Fur? Transfusionsmedizin und Immunham?atologie, 40(5), 302-309 (2013)
Effect of quercetin on cell protection via erythropoietin and cell injury of HepG2 cells
Nishimura K, et al.
Archives of Biochemistry and Biophysics, 636, 11-16 (2017)
Circulating autoantibodies to endogenous erythropoietin are associated with chronic hepatitis C virus infection-related anemia
Tsiakalos A, et al.
Hepatobiliary & Pancreatic Diseases International : HBPD INT, 16(3), 289-295 (2017)
A Gain-of-Function Mutation in EPO in Familial Erythrocytosis
Zmajkovic J, et al.
The New England Journal of Medicine, 378(10), 924-930 (2018)

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