R2533

RS-127445 hydrochloride

≥98% (HPLC), powder

• Sinónimos: 2-Amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine hydrochloride
• Fórmula empírica (notación de Hill): C₁₇H₁₆FN₃ · HCl
• Número de CAS: 199864-86-3
• Peso molecular: 317.79
• MDL number: MFCD11112196
• UNSPSC Code: 12352200
• PubChem Substance ID: 329824019
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to tan
• solubility: DMSO: ≥20 mg/mL
• originator: Roche
• storage temp.: 2-8°C
• SMILES string: Cl.CC(C)c1cc(nc(N)n1)-c2ccc(F)c3ccccc23
• InChI: 1S/C17H16FN3.ClH/c1-10(2)15-9-16(21-17(19)20-15)13-7-8-14(18)12-6-4-3-5-11(12)13;/h3-10H,1-2H3,(H2,19,20,21);1H
• InChI key: MKJPYBJBPRFMHL-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi=9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• pictograms: GHS06
• signalword: Danger
• hcodes: H301,H315,H319,H335
• pcodes: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable