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P3292

Sigma-Aldrich

Pancreatina from porcine pancreas

powder, suitable for cell culture, 4 × USP specifications

Sinónimos:

Pancreatina from hog pancreas

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About This Item

Número de CAS:
8049-47-6
Número CE:
232-468-9
Número MDL:
MFCD00131789
Código UNSPSC:
12352204
NACRES:
NA.75
En este momento no podemos mostrarle ni los precios ni la disponibilidad

origen biológico

Porcine pancreas

Nivel de calidad

200

Agency

USP (specifications)

Formulario

powder

actividad específica

4 × USP specifications

contiene

lactose or sucrose as extender (The sucrose used might contain up to 3.25% starch.)

técnicas

cell culture | mammalian: suitable

Condiciones de envío

ambient

temp. de almacenamiento

−20°C

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Categorías relacionadas

Aplicación

Pancreatin from porcine pancreas has been used to assess the treatment of steatorrhea by lipase supplementation therapy, to investigate treatment options for pancreatic diabetes in patients experiencing the decompensated stage of chronic pancreatitis, and to safely and effectively remove formalin-fixed tissues from arterial grafts without leading to structural damage or loss in fiber integrity.

Acciones bioquímicas o fisiológicas

La pancreatina contiene componentes enzimáticos, como la tripsina, la amilasa y las lipasas, las ribonucleasas y las proteasas, producidas por las células exocrinas de páncreas porcino. Esta combinación de enzimas permite hidrolizar las proteínas, el almidón y las grasas. La pancreatina convertirá no menos de 25 veces su peso de almidón de patata en carbohidratos solubles en 5 minutos en agua a 40 °C, digerirá no menos de 25 veces su peso de caseína en 60 minutos a pH 7,5 a 40 °C y liberará no menos de microequivalentes de ácido por minuto por miligramo de pancreatina del aceite de oliva a pH 9,0 y 37 °C.

Producto relacionado

Referencia del producto
Descripción
Precios

06693

Timestrip Plus™ -20 °C

Pictogramas

Health hazardExclamation mark
GHS08,GHS07

Palabra de señalización

Danger

Frases de peligro

H315,H317,H319,H334,H335

Clasificaciones de peligro

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Órganos de actuación

Respiratory system

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 1

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Certificados de análisis (COA)

Lot/Batch Number
0000365058
0000365058
0000309578
0000339094
SLCM2050

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Daniel N Meijles et al.
The Biochemical journal, 478(11), 2059-2079 (2021-05-19)
Insulin and insulin-like growth factor stimulate protein synthesis and cardioprotection in the heart, acting through their receptors (INSRs, IGF1Rs) and signalling via protein kinase B (PKB, also known as Akt). Protein synthesis is increased in hearts perfused at alkaline pHo
Luisina Ongaro et al.
Biology of reproduction, 102(3), 639-646 (2019-11-15)
Activins selectively stimulate follicle-stimulating hormone (FSH) secretion by pituitary gonadotrope cells. More recently, other members of the TGFbeta superfamily, the bone morphogenetic proteins (BMPs), were reported to regulate FSH synthesis. Activins and BMPs independently and synergistically stimulate transcription of the
Xu-Dong Kong et al.
Nature biomedical engineering, 4(5), 560-571 (2020-05-13)
The oral administration of peptide drugs is hampered by their metabolic instability and limited intestinal uptake. Here, we describe a method for the generation of small target-specific peptides (less than 1,600 Da in size) that resist gastrointestinal proteases. By using
Bruna Maria Salotti de Souza et al.
Probiotics and antimicrobial proteins, 11(2), 382-396 (2018-03-16)
The objective of this study was to evaluate the probiotic properties of Lactobacillus casei and Lactobacillus fermentum strains, as well as to select novel and safe strains for future development of functional fermented products. The in vitro auto-aggregation, co-aggregation, hydrophobicity
Matthew T Pereira et al.
Disease models & mechanisms, 11(12) (2018-12-07)
Increased intestinal barrier permeability has been correlated with aging and disease, including type 2 diabetes, Crohn's disease, celiac disease, multiple sclerosis and irritable bowel syndrome. The prevalence of these ailments has risen together with an increase in industrial food processing
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Questions

1–2 of 2 Questions  

  1. Bonjour, Nous avons besoin de la valeur exacte (chiffrée) de l'activité protease selon monographie USP Pancreatin - Assay for protease activity. Est ce une information disponible sur le CoA du produit ? Ou que nous pouvons obtenir ? Merci d'avance,

    1 answer

    1. The specific activity of the pancreatin is specified in multiples of the minimum USP standard (USP 24, p. 1254). The USP defines a minimum specification of 1X Pancreatin as follows:
      25 USP protease units per mg.
      25 USP amylase units per mg.
      2 USP lipase units per mg.

      For the 4 × USP the above values are multiplied by four. The product Certificate of Analysis confirms that this specification has been met, but no activity values are reported. The USP defines units as:
      One USP Unit of amylase activity is contained in the amount of pancreatin that decomposes starch at an initial rate such that 0.16 µ Eq of glycosidic linkage is hydrolyzed per minute under the conditions of the Assay for amylase activity.

      One USP Unit of lipase activity is contained in the amount of pancreatin that liberates 1.0 µ Eq of acid per minute at a pH of 9.0 and 37° under the conditions of the Assay for lipase activity.

      One USP Unit of protease activity is contained in the amount of pancreatin that under the conditions of the Assay for protease activity hydrolyzes casein at an initial rate such that there is liberated per minute an amount of peptides not precipitated by trichloroacetic acid that gives the same absorbance at 280 nm as 15 nmol of tyrosine.
      The specific monograph may not be shared due to copyright laws. Please refer to the USP to review the published monograph.

      Helpful?

  2. What are the USP/mg for pancreatin (P3292)?

    1 answer

    1. This product meets 4X the minimum USP specifications. According to the USP monograph for Pancreatin, the 1X minimum specification is 25 USP units amylase, 2 USP units lipase, and 25 USP units protease per milligram. The calculated protease activity for the 4X preparation then, would be at least 100 units per milligram. This is a calculated value based on the USP monograph and are not reported separately on the Certificate of Analysis.

      Helpful?

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