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P0099

Sigma-Aldrich

Paliperidone

≥98% (HPLC)

Sinónimos:

3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

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About This Item

Fórmula empírica (notación de Hill):
C23H27FN4O3
Número de CAS:
144598-75-4
Peso molecular:
426.48
Número MDL:
MFCD00871802
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
329820012
NACRES:
NA.77

Nivel de calidad

100

Ensayo

≥98% (HPLC)

Formulario

powder

color

white to brown

solubilidad

DMSO: 2 mg/mL, clear (warmed)

emisor

Johnson & Johnson

temp. de almacenamiento

room temp

cadena SMILES

CC1=C(CCN2CCC(CC2)c3noc4cc(F)ccc34)C(=O)N5CCCC(O)C5=N1

InChI

1S/C23H27FN4O3/c1-14-17(23(30)28-9-2-3-19(29)22(28)25-14)8-12-27-10-6-15(7-11-27)21-18-5-4-16(24)13-20(18)31-26-21/h4-5,13,15,19,29H,2-3,6-12H2,1H3

Clave InChI

PMXMIIMHBWHSKN-UHFFFAOYSA-N

Información sobre el gen

human ... DRD2(1813) , HTR2A(3356)

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Aplicación

Paliperidone has been used as an atypical antipsychotic drug (AAPD) to study its efficacy in preventing psychopathology of mice prenatally immune challenged with lipopolysaccharide (LPS). It has also been used as an atypical antipsychotic drug (AAPD) to explain the modulation of hypothalamic-pituitary-adrenal (HPA) axis in female mice prenatally treated with bacterial endotoxin lipopolysaccharide (LPS).

Acciones bioquímicas o fisiológicas

Paliperidone is an atypical antipsychotic; active metabolite of risperidone.

Características y beneficios

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogramas

Skull and crossbones
GHS06

Palabra de señalización

Danger

Frases de peligro

H301

Clasificaciones de peligro

Acute Tox. 3 Oral

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
0000386255
0000326158
0000326157
0000386255

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Mehrul Hasnain et al.
CNS drugs, 28(10), 887-920 (2014-08-30)
We comprehensively reviewed published literature to determine whether it supported the link between corrected QT (QTc) interval prolongation and torsade de pointes (TdP) for the 11 second-generation antipsychotics and seven second-generation antidepressants commonly implicated in these complications. Using PubMed and
Eliyahu Dremencov et al.
Psychopharmacology, 194(1), 63-72 (2007-05-29)
Paliperidone (9-OH-risperidone) is the main metabolite of the atypical antipsychotic risperidone. While both drugs are potent dopamine (D)2 antagonists, they have quantitative differential affinities for serotonin (5-HT) and norepinephrine (NE) receptor binding sites. The present study aimed to determine if
Umesh Kumar et al.
European journal of pharmacology, 747, 181-189 (2014-09-23)
Studies on animal models provide enough evidences that old age appearance of psychosis on exposures to various insults during critical period of brain development could be prevented by antipsychotic drug treatment. Presently, gestational intervention of the atypical antipsychotic paliperidone (PAL)
Mariana Zuccherato Bocato et al.
Analytica chimica acta, 742, 80-89 (2012-08-14)
The present work describes for the first time the use of SPME coupled to LC-MS/MS employing the polar organic mode in a stereoselective fungal biotransformation study to investigate the fungi ability to biotransform the drug risperidone into its chiral and
Sacheen Kumar et al.
Colloids and surfaces. B, Biointerfaces, 102, 562-568 (2012-10-30)
Solid lipid nanoparticles were prepared and studied for the possibility of entrapment of Paliperidone (PPN) an antipsychotic drug that can be used for the treatment of schizophrenia. Here we report the preparation of Paliperidone loaded solid lipid particles (SLNs) with
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