M7033

N^G-Methyl-L-arginine acetate salt

≥98% (TLC), powder, nitric oxide synthase inhibitor

• Sinónimos: N_ω-Methyl-L-arginine acetate salt, L-NMMA, N⁵-(Methylamidino)-L-ornithine acetate salt, N^G-Monomethyl-L-arginine acetate salt
• Fórmula empírica (notación de Hill): C₇H₁₆N₄O₂ · C₂H₄O₂
• Número de CAS: 53308-83-1
• Peso molecular: 248.28
• Beilstein: 6674255
• Número MDL: MFCD00069311
• Código UNSPSC: 12352209
• ID de la sustancia en PubChem: 24278043
• NACRES: NA.77

Propiedades

• Nombre del producto: N^G-Methyl-L-arginine acetate salt, ≥98% (TLC)
• Nivel de calidad: 200
• Ensayo: ≥98% (TLC)
• Formulario: powder
• solubilidad: water: 49.00-51.00 mg/mL, clear to very slightly hazy, colorless to faintly yellow
• cadena SMILES: CC(O)=O.CNC(=N)NCCC[C@H](N)C(O)=O
• InChI: 1S/C7H16N4O2.C2H4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13;1-2(3)4/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11);1H3,(H,3,4)/t5-;/m0./s1
• Clave InChI: IKPNWIGTWUZCKM-JEDNCBNOSA-N
• Información sobre el gen: human ... NOS1(4842) , NOS2(4843) , NOS3(4846) ; mouse ... Nos2(18126) ; rat ... Nos1(24598) , Nos2(24599)

Descripción

Aplicación

N^G-Methyl-L-arginine acetate salt has been used:

• as an inhibitor of nitric oxide synthase (NOS) in wound healing studies in injured mice
• as an inhibitor of nitric oxide synthase (NOS) to study nitric oxide (NO) immunosuppressive effect of murine stem cells
• as an inhibitor to monitor NO levels in hemocytes respiratory burst assay

Acciones bioquímicas o fisiológicas

N^G-Methyl-L-arginine is an inhibitor of nitric oxide synthase in neurons, endothelial cells, and macrophages. It inhibits endothelium-derived relaxing factor and promotes contraction in pulmonary artery and vein. It stereo selectively inhibits the generation of nitric oxide (NO) from arginine. It promotes epinephrine and glucose levels, contributing to hyperglycemia in central nervous system.

Características y beneficios

This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)