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Merck

L1645

Sigma-Aldrich

Anti-Human Lambda Light Chain (Bound and Free) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

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About This Item

Número MDL:
Código UNSPSC:
12352203
NACRES:
NA.46

origen biológico

goat

Nivel de calidad

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

secondary antibodies

clon

polyclonal

Formulario

buffered aqueous solution

técnicas

indirect ELISA: 1:2,500

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

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Descripción general

Immunoglobulins (Ig) are produced by the B cells and play crucial role in host humoral immune response. A typical immunoglobulin consists of two heavy chains and two light chains. The two light chains are either κ or the λ chain. The B cells express one type of light chain during their life time.
Lambda (λ) light chain comprises an amino-terminal variable region and carboxy-terminal constant region. λ chain is biologically critical and constitutes up to 30 to 40% of human immunoglobulin (Ig) molecules. The human λ locus is mapped to the chromosome location 22.

Aplicación

Anti-Human Lambda Light Chain (Bound and Free) antibody has been used in surface plasmon resonance assay.
Anti-Human Lambda Light Chain (bound and free) antibody produced in goat has been used in indirect enzyme linked immuno sorbent assay (ELISA).

Forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as preservative

Almacenamiento y estabilidad

For continuous use, store at 2-8 °C for up to one month.For extended storage, solution may be frozen inworking aliquots. Repeated freezing and thawing is notrecommended. Storage in "frost-free" freezers is notrecommended.If slight turbidity occurs upon prolonged storage, clarify by centrifugation before use.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

nwg

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Structural and functional properties of human lambda-light-chain variable-region subgroups.
A Solomon et al.
Clinical and diagnostic laboratory immunology, 2(4), 387-394 (1995-07-01)
B-cell development
Hematology (2018)
Adam W Clarke et al.
mAbs, 10(4), 664-677 (2018-02-14)
TL1A is an attractive therapeutic target for the treatment of mucosal inflammation associated with inflammatory bowel disease (IBD) and asthma. Blockade of the TL1A pathway has been shown to reduce inflammatory responses while leaving baseline immunity intact, and to be
Jinhao Bi et al.
Emerging microbes & infections, 12(1), 2149351-2149351 (2022-12-02)
Marburg virus disease (MVD) is a lethal viral haemorrhagic fever caused by Marburg virus (MARV) with a case fatality rate as high as 88%. There is currently no vaccine or antiviral therapy approved for MVD. Due to high variation among
Jerry A Katzmann et al.
Clinical chemistry, 48(9), 1437-1444 (2002-08-27)
The detection of monoclonal free light chains (FLCs) is an important diagnostic aid for a variety of monoclonal gammopathies and is especially important in light-chain diseases, such as light-chain myeloma, primary systemic amyloidosis, and light-chain-deposition disease. These diseases are more

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