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K1136

Sigma-Aldrich

Ketorolac tris salt

≥99%, crystalline

Sinónimos:

(±)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid tris salt, Toradol

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About This Item

Fórmula empírica (notación de Hill):
C15H13NO3 · C4H11NO3
Número de CAS:
74103-07-4
Peso molecular:
376.40
Número MDL:
MFCD00887595
Código UNSPSC:
12352202
ID de la sustancia en PubChem:
24278503
NACRES:
NA.77

origen biológico

synthetic (organic)

Nivel de calidad

100

Ensayo

≥99%

Formulario

crystalline

solubilidad

H2O: soluble 15 mg/mL, clear, colorless to faintly yellow (stable at least one month at −20 °C.)

temp. de almacenamiento

room temp

cadena SMILES

NC(CO)(CO)CO.OC(=O)C1CCn2c1ccc2C(=O)c3ccccc3

InChI

1S/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13;5-4(1-6,2-7)3-8/h1-7,11H,8-9H2,(H,18,19);6-8H,1-3,5H2

Clave InChI

BWHLPLXXIDYSNW-UHFFFAOYSA-N

Información sobre el gen

human ... PTGS1(5742) , PTGS2(5743)

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Aplicación

Ketorolac has been used:
  • as an intraperitoneal injection in mice to study the effect of ketorolac on expression of c-Fos (a human proto-oncogene) in ARC (arcuate nucleus of the hypothalamus) POMC (proopiomelanocortin) -EGFP (enhanced green fluorescent protein) neurons
  • to treat mice in order to show that this treatment does not prevent IL-1β-mediated inhibition of Agouti-related protein (AgRP) secretion from murine hypothalamic explants
  • as an analgesic medication to treat rats induced with acute inflammatory joint injury by injecting carrageenan into the ankle

Acciones bioquímicas o fisiológicas

Ketorolac is a non-steroidal agent that possesses moderate anti-inflammatory activity and is also a potent analgesic. It shows superior analgesic efficacy to that of the opioid analgesics like morphine in patients with moderate to severe postsurgical pain. It inhibits prostaglandin synthesis and platelet aggregation induced by arachidonic acid and collagen. It is a dual COX-1/COX-2 inhibitor.

Precaución

Stable at least 2 years if stored at room temperature.

Aplicación

Referencia del producto
Descripción
Precios

Pictogramas

Skull and crossbones
GHS06

Palabra de señalización

Danger

Frases de peligro

H301,H315,H319,H335

Clasificaciones de peligro

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órganos de actuación

Respiratory system

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
MKCW9383
MKCV0186
MKCQ7512
MKCJ8295
MKCH2969

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R A Dionne et al.
Clinical and experimental rheumatology, 19(6 Suppl 25), S63-S70 (2001-11-07)
While non-steroidal anti-inflammatory drugs (NSAIDs) are the mainstay of therapy for the management of acute pain and rheumatoid arthritis, toxicity associated with chronic administration limits their benefit-to-risk relationship in many patients. A series of studies is reviewed that assesses the
Rachel L Ruhlen et al.
The Journal of the American Osteopathic Association, 113(10), 738-752 (2013-10-03)
Animal models can be used to investigate manual therapy mechanisms, but testing manipulation in animal models is problematic because animals cannot directly report their pain. To develop a rat model of inflammatory joint injury to test the efficacy of manual
O Laneuville et al.
The Journal of pharmacology and experimental therapeutics, 271(2), 927-934 (1994-11-01)
We developed an in vitro expression system for accurate kinetic analyses of the inhibition of the human prostaglandin H synthase isozymes (hPGHS-1 and -2) by nonsteroidal anti-inflammatory drugs (NSAIDs). Assays of instantaneous inhibition in which enzyme, 10 microM arachidonate, and
M M Buckley et al.
Drugs, 39(1), 86-109 (1990-01-01)
Ketorolac is a non-steroidal agent with potent analgesic and moderate anti-inflammatory activity. It is administered as the tromethamine salt orally, intramuscularly, intravenously, and as a topical ophthalmic solution. Clinical studies indicate single-dose efficacy greater than that of morphine, pethidine (meperidine)
Jarrad M Scarlett et al.
Endocrinology, 148(9), 4217-4225 (2007-05-26)
Anorexia and involuntary weight loss are common and debilitating complications of a number of chronic diseases and inflammatory states. Proinflammatory cytokines, including IL-1 beta, are hypothesized to mediate these responses through direct actions on the central nervous system. However, the
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